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Literature summary extracted from

  • Jun, H.K.; Yeeh, Y.
    Purification and charaterization of an extracellular adenosine deaminase from Nocardioides sp. J-326TK (1994), Biotechnol. Appl. Biochem., 20, 265-277.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.4.4 medicine therapy for adenosine-deficient patients with combined immunodeficiency Nocardioides sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.4 8-Bromoadenosine
-
 Nocardioides sp.
3.5.4.4 Ag2+
-
 Nocardioides sp.
3.5.4.4 Cd2+
-
 Nocardioides sp.
3.5.4.4 Hg2+
-
 Nocardioides sp.
3.5.4.4 Mg2+
-
 Nocardioides sp.
3.5.4.4 Mn2+
-
 Nocardioides sp.
3.5.4.4 o-phenanthroline
-
 Nocardioides sp.
3.5.4.4 Pentachlorophenol
-
 Nocardioides sp.
3.5.4.4 Theobromine
-
 Nocardioides sp.
3.5.4.4 theophylline
-
 Nocardioides sp.
3.5.4.4 Zn2+
-
 Nocardioides sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.4 0.2
-
 2'-deoxyadenosine
-
 Nocardioides sp.
3.5.4.4 0.22
-
 adenosine
-
 Nocardioides sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.4.4 extracellular
-
 Nocardioides sp.
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.4.4 Fe3+
-
 Nocardioides sp.
3.5.4.4 Sn2+
-
 Nocardioides sp.

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.4 72000
-
 SDS-PAGE Nocardioides sp.
3.5.4.4 80000
-
 gel filtration Nocardioides sp.

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.4 Nocardioides sp.
-
 J-326TK
-
3.5.4.4 Nocardioides sp. J-326TK
-
 J-326TK
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.4 4677
-
-
 Nocardioides sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.4 2',3'-isopropylideneadenosine + H2O
-
 Nocardioides sp. 2',3'-isopropylideneinosine + NH3
-
 ir
3.5.4.4 2',3'-isopropylideneadenosine + H2O
-
 Nocardioides sp. J-326TK 2',3'-isopropylideneinosine + NH3
-
 ir
3.5.4.4 2'-deoxyadenosine + H2O
-
 Nocardioides sp. 2'-deoxyinosine + NH3
-
 ir
3.5.4.4 2'-deoxyadenosine + H2O
-
 Nocardioides sp. J-326TK 2'-deoxyinosine + NH3
-
 ir
3.5.4.4 5'-AMP + H2O
-
 Nocardioides sp. 5'-IMP + NH3
-
 ir
3.5.4.4 5'-AMP + H2O
-
 Nocardioides sp. J-326TK 5'-IMP + NH3
-
 ir
3.5.4.4 adenosine + H2O
-
 Nocardioides sp. inosine + NH3
-
 ir
3.5.4.4 adenosine + H2O
-
 Nocardioides sp. J-326TK inosine + NH3
-
 ir
3.5.4.4 adenosine-3'-monophosphate + H2O
-
 Nocardioides sp. IMP-3'-monophosphate + NH3
-
 ir
3.5.4.4 ADP + H2O
-
 Nocardioides sp. 5'-IDP + NH3
-
 ir
3.5.4.4 ADP + H2O
-
 Nocardioides sp. J-326TK 5'-IDP + NH3
-
 ir
3.5.4.4 ATP + H2O
-
 Nocardioides sp. ITP + NH3
-
 ir

Subunits

EC Number Subunits Comment Organism
3.5.4.4 monomer 72000, SDS-PAGE Nocardioides sp.

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.4 50
-
-
 Nocardioides sp.

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.5.4.4 20 65
-
 Nocardioides sp.

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.4.4 30
-
 30°C and below Nocardioides sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.4 6 6.5
-
 Nocardioides sp.

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.5.4.4 6.5 7.5
-
 Nocardioides sp.