Literature summary extracted from

  • Daddona, P.E.; Wiesmann, W.P.; Lambros, C.; Kelley, W.N.; Webster, H.K.
    Human malaria parasite adenosine deaminase (1984), J. Biol. Chem., 259, 1472-1475.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.4 2,6-diaminopurine
-
Homo sapiens
3.5.4.4 2,6-diaminopurine
-
Plasmodium falciparum
3.5.4.4 6-methylamino riboside
-
Homo sapiens
3.5.4.4 6-methylamino riboside
-
Plasmodium falciparum
3.5.4.4 6-Methylmercaptopurine riboside
-
Homo sapiens
3.5.4.4 6-Methylmercaptopurine riboside
-
Plasmodium falciparum
3.5.4.4 adenine
-
Homo sapiens
3.5.4.4 adenine
-
Plasmodium falciparum
3.5.4.4 cordycepin
-
Homo sapiens
3.5.4.4 cordycepin
-
Plasmodium falciparum
3.5.4.4 Deoxycoformycin
-
Homo sapiens
3.5.4.4 erythro-9-(2-hydroxy-3-nonyl)adenine
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.4 0.057
-
2'-deoxyadenosine
-
Plasmodium falciparum
3.5.4.4 0.049
-
adenosine
-
Homo sapiens
3.5.4.4 0.053
-
2'-deoxyadenosine
-
Homo sapiens
3.5.4.4 0.051
-
adenosine
-
Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.4 Homo sapiens
-
normal B-cells and T-cell lines MOLT-4
-
3.5.4.4 Homo sapiens
-
RPMI-8402
-
3.5.4.4 Homo sapiens
-
CCRF-CEM
-
3.5.4.4 Plasmodium falciparum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.4 erythrocyte malaria-infected Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.4 0.003
-
-
Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.4 adenosine + H2O
-
Homo sapiens inosine + NH3
-
?
3.5.4.4 adenosine + H2O
-
Plasmodium falciparum inosine + NH3
-
?
3.5.4.4 2'-deoxyadenosine + H2O
-
Homo sapiens 2'-deoxyinosine + NH3
-
?
3.5.4.4 2'-deoxyadenosine + H2O
-
Plasmodium falciparum 2'-deoxyinosine + NH3
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.4 5 8
-
Homo sapiens
3.5.4.4 5 8
-
Plasmodium falciparum