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Literature summary extracted from
- Histochemical and biochemical studies on guanase in the human and rat kidney (1991), Acta Histochem., 24, 591-596.
No PubMed abstract available
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.5.4.3 | medicine | enzyme has been implicated in cancer, liver disease, saturine gout, psoriasis and autoimmune disease, histochemical method for demonstration of guanase should be useful clinically, guanase activity increases significantly in lung and gastric cancer tissues or in patients with liver diseases like hepatitis, guanase is a biochemical indicator of rejection in liver transplant recipients, serum enzyme activity is the most sensitive indicator of liver disease, inhibition of guanase has beneficial implications in cancer chemotherapy, an inhibitor as chemotherapeutic agent selectively inhibit the growth of rapidly proliferating cancerous cells via depletion of the purine nucleotide pool | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.3 | guanine + H2O | Mus musculus | - |
xanthine + NH3 | - |
? |  |
| 3.5.4.3 | guanine + H2O | Homo sapiens | - |
xanthine + NH3 | - |
? | |
| 3.5.4.3 | guanine + H2O | Rattus norvegicus | - |
xanthine + NH3 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.3 | Homo sapiens | - |
human | - |
| 3.5.4.3 | Mus musculus | - |
mouse | - |
| 3.5.4.3 | Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.4.3 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.4.3 | brain | - |
Mus musculus | - |
| 3.5.4.3 | brain | - |
Homo sapiens | - |
| 3.5.4.3 | brain | - |
Rattus norvegicus | - |
| 3.5.4.3 | heart | - |
Homo sapiens | - |
| 3.5.4.3 | kidney | - |
Homo sapiens | - |
| 3.5.4.3 | kidney | - |
Rattus norvegicus | - |
| 3.5.4.3 | liver | - |
Mus musculus | - |
| 3.5.4.3 | liver | - |
Homo sapiens | - |
| 3.5.4.3 | liver | - |
Rattus norvegicus | - |
| 3.5.4.3 | skeletal muscle | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.3 | guanine + H2O | - |
Mus musculus | xanthine + NH3 | - |
? | |
| 3.5.4.3 | guanine + H2O | - |
Homo sapiens | xanthine + NH3 | - |
? | |
| 3.5.4.3 | guanine + H2O | - |
Rattus norvegicus | xanthine + NH3 | - |
? | |
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Release 2023.1 (January 2023)
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