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Literature summary extracted from

  • Gupta, N.K.; Glantz, M.D.
    Isolation and characterization of human liver guanine deaminase (1985), Arch. Biochem. Biophys., 236, 266-276.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.3 5-aminoimidazole-4-carboxamide
-
Homo sapiens
3.5.4.3 5-aminoimidazole-4-carboxamide
-
Oryctolagus cuniculus
3.5.4.3 5-aminoimidazole-4-carboxamide
-
Rattus norvegicus
3.5.4.3 5-aminoimidazole-4-carboxamide ribonucleoside
-
Oryctolagus cuniculus
3.5.4.3 5-aminoimidazole-4-carboxamide ribonucleoside
-
Rattus norvegicus
3.5.4.3 iodoacetamide 2 mM mildly inhibitory Oryctolagus cuniculus
3.5.4.3 iodoacetic acid 0.1 mM 7% loss in the activity, 1 mM 29% loss in the activity after 30 min incubation Homo sapiens
3.5.4.3 iodoacetic acid
-
Oryctolagus cuniculus
3.5.4.3 p-hydroxymercuribenzoate 0.0001 M 91% loss of activity after 30 min incubation Homo sapiens
3.5.4.3 p-hydroxymercuribenzoate
-
Oryctolagus cuniculus
3.5.4.3 p-hydroxymercuribenzoate
-
Rattus norvegicus
3.5.4.3 tetrahydrofolic acid
-
Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.3 0.0038
-
guanine
-
Oryctolagus cuniculus
3.5.4.3 0.0042
-
guanine
-
Bos taurus
3.5.4.3 0.0056
-
guanine
-
Homo sapiens
3.5.4.3 0.0056
-
guanine
-
Oryctolagus cuniculus
3.5.4.3 0.011
-
guanine
-
Sus sp.
3.5.4.3 0.0125
-
guanine at pH 7 Oryctolagus cuniculus
3.5.4.3 0.0153
-
guanine at pH 6 Homo sapiens
3.5.4.3 0.0156
-
guanine at pH 8.0 Homo sapiens
3.5.4.3 0.0166
-
guanine at pH 7.0 Homo sapiens
3.5.4.3 0.0178
-
guanine at pH 7.5 Homo sapiens
3.5.4.3 0.0182
-
guanine
-
Oryctolagus cuniculus
3.5.4.3 0.0182
-
guanine at pH 6 Homo sapiens
3.5.4.3 0.02
-
guanine at pH 6.5 Homo sapiens
3.5.4.3 0.0313
-
guanine at pH 5.5 Homo sapiens
3.5.4.3 0.037
-
guanine at pH 9.0 Homo sapiens
3.5.4.3 0.0417
-
guanine at pH 8.5 Homo sapiens
3.5.4.3 0.105
-
guanine
-
Oryctolagus cuniculus
3.5.4.3 0.17
-
guanine
-
Rattus norvegicus
3.5.4.3 0.2
-
8-Azaguanine at pH 6 Homo sapiens
3.5.4.3 0.23
-
8-Azaguanine
-
Oryctolagus cuniculus
3.5.4.3 0.33
-
8-Azaguanine
-
Sus sp.
3.5.4.3 0.333
-
8-Azaguanine at pH 6 Oryctolagus cuniculus
3.5.4.3 0.67
-
8-Azaguanine
-
Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.3 50000
-
2 * 50000, SDS-PAGE Homo sapiens
3.5.4.3 50000
-
2 * 50000, SDS-PAGE Oryctolagus cuniculus
3.5.4.3 50000
-
2 * 50000, SDS-PAGE Sus sp.
3.5.4.3 52000
-
2 * 52000, brain and liver enzymes, SDS-PAGE Rattus norvegicus
3.5.4.3 52000
-
2 * 52000, brain and liver enzymes, SDS-PAGE Bos taurus
3.5.4.3 52000
-
2 * 52000, brain and liver enzymes, SDS-PAGE Oryctolagus cuniculus
3.5.4.3 55000
-
-
Homo sapiens
3.5.4.3 55000
-
liver, single polypeptide chain, gel filtration Rattus norvegicus
3.5.4.3 55000
-
liver, single polypeptide chain, gel filtration Oryctolagus cuniculus
3.5.4.3 55000
-
2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Sus sp.
3.5.4.3 59000
-
-
Oryctolagus cuniculus
3.5.4.3 59000
-
2 * 59000, SDS-PAGE Homo sapiens
3.5.4.3 95000
-
-
Bos taurus
3.5.4.3 100000
-
-
Homo sapiens
3.5.4.3 100000
-
2 forms of liver enzyme Oryctolagus cuniculus
3.5.4.3 105000
-
-
Rattus norvegicus
3.5.4.3 105000
-
-
Bos taurus
3.5.4.3 110000
-
-
Rattus norvegicus
3.5.4.3 110000
-
-
Sus sp.
3.5.4.3 110000
-
liver, gel filtration Homo sapiens
3.5.4.3 110000
-
liver, gel filtration Oryctolagus cuniculus
3.5.4.3 120000
-
gel filtration Homo sapiens
3.5.4.3 170000
-
2 forms of liver enzyme Oryctolagus cuniculus
3.5.4.3 200000
-
-
Homo sapiens
3.5.4.3 207000
-
2 forms of liver enzyme Oryctolagus cuniculus
3.5.4.3 525000
-
2 forms of liver enzyme Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.3 guanine + H2O Homo sapiens
-
xanthine + NH3
-
?
3.5.4.3 guanine + H2O Rattus norvegicus
-
xanthine + NH3
-
?
3.5.4.3 guanine + H2O Bos taurus
-
xanthine + NH3
-
?
3.5.4.3 guanine + H2O Oryctolagus cuniculus
-
xanthine + NH3
-
?
3.5.4.3 guanine + H2O Sus sp.
-
xanthine + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.3 Bos taurus
-
cow
-
3.5.4.3 Homo sapiens
-
human
-
3.5.4.3 Oryctolagus cuniculus
-
rabbit
-
3.5.4.3 Rattus norvegicus
-
rat
-
3.5.4.3 Sus sp.
-
pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.3
-
Homo sapiens
3.5.4.3
-
Bos taurus
3.5.4.3
-
Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.3 liver
-
Homo sapiens
-
3.5.4.3 liver
-
Rattus norvegicus
-
3.5.4.3 liver
-
Bos taurus
-
3.5.4.3 liver
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.3 21.5
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.3 6-thioguanine + H2O
-
Oryctolagus cuniculus 6-thioxanthine + NH3
-
?
3.5.4.3 6-thioguanine + H2O
-
Sus sp. 6-thioxanthine + NH3
-
?
3.5.4.3 8-azaguanine + H2O
-
Homo sapiens 8-azaxanthine + NH3
-
?
3.5.4.3 8-azaguanine + H2O
-
Rattus norvegicus 8-azaxanthine + NH3
-
?
3.5.4.3 8-azaguanine + H2O
-
Oryctolagus cuniculus 8-azaxanthine + NH3
-
?
3.5.4.3 8-azaguanine + H2O
-
Sus sp. 8-azaxanthine + NH3
-
?
3.5.4.3 guanine + H2O
-
Homo sapiens xanthine + NH3
-
?
3.5.4.3 guanine + H2O
-
Rattus norvegicus xanthine + NH3
-
?
3.5.4.3 guanine + H2O
-
Bos taurus xanthine + NH3
-
?
3.5.4.3 guanine + H2O
-
Oryctolagus cuniculus xanthine + NH3
-
?
3.5.4.3 guanine + H2O
-
Sus sp. xanthine + NH3
-
?

Subunits

EC Number Subunits Comment Organism
3.5.4.3 dimer 2 * 50000, SDS-PAGE Homo sapiens
3.5.4.3 dimer 2 * 50000, SDS-PAGE Oryctolagus cuniculus
3.5.4.3 dimer 2 * 50000, SDS-PAGE Sus sp.
3.5.4.3 dimer 2 * 59000, SDS-PAGE Homo sapiens
3.5.4.3 dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Homo sapiens
3.5.4.3 dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Oryctolagus cuniculus
3.5.4.3 dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Sus sp.
3.5.4.3 dimer 2 * 52000, brain and liver enzymes, SDS-PAGE Rattus norvegicus
3.5.4.3 dimer 2 * 52000, brain and liver enzymes, SDS-PAGE Bos taurus
3.5.4.3 dimer 2 * 52000, brain and liver enzymes, SDS-PAGE Oryctolagus cuniculus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.4.3 40
-
-
Oryctolagus cuniculus
3.5.4.3 40
-
stable up to Homo sapiens
3.5.4.3 45
-
relatively stable, incubation for 5 min, 3% loss in activity, 17% after 30 min Homo sapiens
3.5.4.3 55
-
-
Oryctolagus cuniculus
3.5.4.3 55
-
becomes labile at, loses 21% of activity after 5 min incubation, 49% after 30 min Homo sapiens
3.5.4.3 65
-
activity completely lost after 30 min incubation Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.3 5.9
-
liver enzyme Oryctolagus cuniculus
3.5.4.3 6
-
8-azaguanine as substrate Homo sapiens
3.5.4.3 6
-
8-azaguanine as substrate Oryctolagus cuniculus
3.5.4.3 6.8
-
-
Oryctolagus cuniculus
3.5.4.3 8
-
-
Homo sapiens
3.5.4.3 8
-
-
Rattus norvegicus
3.5.4.3 8
-
-
Oryctolagus cuniculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.4.3 5.5 9
-
Homo sapiens