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Literature summary extracted from

  • Suzuki, T.; Ohye, T.; Inagaki, H.; Nagatsu, T.; Ichinose, H.
    Characterization of wild-type and mutants of recombinant human GTP-cyclohydrolase I: Relationship to etiology of dopa-responsive dystonia (1999), J. Neurochem., 73, 2510-2516.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.4.16 expression in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.5.4.16 G201E no activity at 0.1 mM GTP Homo sapiens
3.5.4.16 M211I low activity at 0.1 mM GTP Homo sapiens
3.5.4.16 R184H very low activity at 0.1 mM GTP Homo sapiens
3.5.4.16 R88W very low activity at 0.1 mM GTP Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.16 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.16 expression of wild-type and mutant proteins in Escherichia coli Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.16 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.16 GTP + H2O
-
 Homo sapiens formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?