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Literature summary extracted from

  • Blau, N.; Niederwieser, A.
    GTP-cyclohydrolases: mini-review (1984), Biochem. Clin. Aspects Pteridines, 3, 77-92.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.16 ADP competitive inhibitor Escherichia coli
3.5.4.16 ATP
-
 Drosophila melanogaster
3.5.4.16 ATP competitive inhibitor Escherichia coli
3.5.4.16 ATP
-
 Serratia indica
3.5.4.16 Ca2+
-
 Drosophila melanogaster
3.5.4.16 Ca2+
-
 Geobacillus stearothermophilus
3.5.4.16 Cu2+
-
 Escherichia coli
3.5.4.16 Cu2+
-
 Gallus gallus
3.5.4.16 Cu2+
-
 Geobacillus stearothermophilus
3.5.4.16 Cu2+
-
 Rattus norvegicus
3.5.4.16 Cu2+
-
 Serratia indica
3.5.4.16 dGTP
-
 Drosophila melanogaster
3.5.4.16 dGTP competitive inhibitor Escherichia coli
3.5.4.16 GDP
-
 Drosophila melanogaster
3.5.4.16 GDP
-
 Serratia indica
3.5.4.16 guanosine 5'-tetraphosphate
-
 Escherichia coli
3.5.4.16 Hg2+
-
 Escherichia coli
3.5.4.16 Hg2+
-
 Gallus gallus
3.5.4.16 Hg2+
-
 Geobacillus stearothermophilus
3.5.4.16 Hg2+
-
 Serratia indica
3.5.4.16 Mg2+
-
 Drosophila melanogaster
3.5.4.16 Mg2+
-
 Lactiplantibacillus plantarum
3.5.4.16 Mg2+
-
 Rattus norvegicus
3.5.4.16 PO43- uncompetitive inhibitor Escherichia coli
3.5.4.16 TTP competitive inhibitor Escherichia coli
3.5.4.16 UTP competitive inhibitor Escherichia coli
3.5.4.16 Zn2+
-
 Drosophila melanogaster
3.5.4.16 Zn2+
-
 Serratia indica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.16 additional information
-
 additional information
-
 Lactiplantibacillus plantarum
3.5.4.16 additional information
-
 additional information
-
 Escherichia coli
3.5.4.16 additional information
-
 additional information
-
 Rattus norvegicus
3.5.4.16 additional information
-
 additional information
-
 Geobacillus stearothermophilus
3.5.4.16 additional information
-
 additional information
-
 Serratia indica
3.5.4.16 additional information
-
 additional information
-
 Comamonas sp.

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.4.16 Mg2+ activates Escherichia coli
3.5.4.16 Mg2+ activates Rattus norvegicus
3.5.4.16 Mg2+ activates Comamonas sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.16 GTP + H2O Lactiplantibacillus plantarum first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Escherichia coli first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Rattus norvegicus first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Geobacillus stearothermophilus first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Serratia indica first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Comamonas sp. first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.16 Comamonas sp.
-
-
-
3.5.4.16 Drosophila melanogaster
-
-
-
3.5.4.16 Escherichia coli
-
-
-
3.5.4.16 Gallus gallus
-
-
-
3.5.4.16 Geobacillus stearothermophilus
-
-
-
3.5.4.16 Lactiplantibacillus plantarum
-
 alpha1, alpha and beta
-
3.5.4.16 Rattus norvegicus
-
-
-
3.5.4.16 Serratia indica
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.16 brain
-
 Rattus norvegicus
-
3.5.4.16 kidney
-
 Rattus norvegicus
-
3.5.4.16 liver
-
 Gallus gallus
-
3.5.4.16 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.16 GTP + H2O
-
 Gallus gallus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Drosophila melanogaster formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Lactiplantibacillus plantarum formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Escherichia coli formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Geobacillus stearothermophilus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Serratia indica formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Comamonas sp. formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Lactiplantibacillus plantarum formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Escherichia coli formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Geobacillus stearothermophilus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Serratia indica formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Comamonas sp. formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.16 additional information
-
-
 Lactiplantibacillus plantarum
3.5.4.16 additional information
-
-
 Escherichia coli
3.5.4.16 additional information
-
-
 Rattus norvegicus
3.5.4.16 additional information
-
-
 Geobacillus stearothermophilus
3.5.4.16 additional information
-
-
 Serratia indica
3.5.4.16 additional information
-
-
 Comamonas sp.