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Literature summary extracted from

  • Blau, N.; Niederwieser, A.
    GTP-cyclohydrolases: a review (1985), J. Clin. Chem. Clin. Biochem., 23, 169-176.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.16 Cu2+
-
 Escherichia coli
3.5.4.16 Cu2+
-
 Geobacillus stearothermophilus
3.5.4.16 Cu2+
-
 Rattus norvegicus
3.5.4.16 Cu2+
-
 Serratia indica
3.5.4.16 Fe3+
-
 Serratia indica
3.5.4.16 GTP substrate inhibition above 0.2 mM Rattus norvegicus
3.5.4.16 Hg2+
-
 Escherichia coli
3.5.4.16 Hg2+
-
 Geobacillus stearothermophilus
3.5.4.16 Hg2+
-
 Serratia indica
3.5.4.16 Mg2+
-
 Lactiplantibacillus plantarum
3.5.4.16 Mg2+
-
 Rattus norvegicus
3.5.4.16 PO43-
-
 Escherichia coli
3.5.4.16 Zn2+
-
 Serratia indica
3.5.4.25 Cu2+
-
 Meyerozyma guilliermondii
3.5.4.25 diphosphate
-
 Escherichia coli
3.5.4.25 diphosphate
-
 Meyerozyma guilliermondii
3.5.4.25 phosphate
-
 Meyerozyma guilliermondii
3.5.4.25 Zn2+
-
 Meyerozyma guilliermondii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.16 additional information
-
 additional information
-
 Mammalia
3.5.4.16 additional information
-
 additional information
-
 Lactiplantibacillus plantarum
3.5.4.16 additional information
-
 additional information
-
 Escherichia coli
3.5.4.16 additional information
-
 additional information
-
 Rattus norvegicus
3.5.4.16 additional information
-
 additional information
-
 Geobacillus stearothermophilus
3.5.4.16 additional information
-
 additional information
-
 Serratia indica
3.5.4.16 additional information
-
 additional information
-
 Comamonas sp.
3.5.4.25 0.22
-
 GTP
-
 Meyerozyma guilliermondii
3.5.4.25 0.41
-
 GTP
-
 Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.4.25 Mg2+ Mg2+ dependent Escherichia coli
3.5.4.25 Mg2+ Mg2+ dependent Meyerozyma guilliermondii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.16 105000
-
 gel filtration Geobacillus stearothermophilus
3.5.4.25 44000
-
-
 Escherichia coli
3.5.4.25 170000
-
 gel filtration Meyerozyma guilliermondii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.16 GTP + H2O Mammalia first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Lactiplantibacillus plantarum first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Escherichia coli first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Rattus norvegicus first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Geobacillus stearothermophilus first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Serratia indica first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O Comamonas sp. first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.25 GTP + H2O Escherichia coli
-
 formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate
-
 ?
3.5.4.25 GTP + H2O Meyerozyma guilliermondii
-
 formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.16 Comamonas sp.
-
-
-
3.5.4.16 Escherichia coli
-
-
-
3.5.4.16 Geobacillus stearothermophilus
-
-
-
3.5.4.16 Lactiplantibacillus plantarum
-
-
-
3.5.4.16 Mammalia
-
-
-
3.5.4.16 Rattus norvegicus
-
-
-
3.5.4.16 Serratia indica
-
-
-
3.5.4.25 Escherichia coli
-
-
-
3.5.4.25 Meyerozyma guilliermondii
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.16 brain
-
 Rattus norvegicus
-
3.5.4.16 kidney
-
 Rattus norvegicus
-
3.5.4.16 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.16 GTP + H2O
-
 Mammalia formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Lactiplantibacillus plantarum formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Escherichia coli formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Geobacillus stearothermophilus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Serratia indica formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Comamonas sp. formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Mammalia formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Lactiplantibacillus plantarum formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Escherichia coli formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Geobacillus stearothermophilus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Serratia indica formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in pathway of pterins Comamonas sp. formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
3.5.4.25 GTP + H2O
-
 Escherichia coli formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate
-
 ?
3.5.4.25 GTP + H2O
-
 Meyerozyma guilliermondii formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.16 additional information
-
-
 Mammalia
3.5.4.16 additional information
-
-
 Lactiplantibacillus plantarum
3.5.4.16 additional information
-
-
 Escherichia coli
3.5.4.16 additional information
-
-
 Rattus norvegicus
3.5.4.16 additional information
-
-
 Geobacillus stearothermophilus
3.5.4.16 additional information
-
-
 Serratia indica
3.5.4.16 additional information
-
-
 Comamonas sp.
3.5.4.25 8.2
-
-
 Meyerozyma guilliermondii
3.5.4.25 8.5
-
-
 Escherichia coli