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Literature summary extracted from

  • Sawada, M.; Horikoshi, T.; Masada, M.; Akino, M.; Sugimoto, T.M.; Matsuura, S.; Nagatsu, T.
    A sensitive assay of GTP cyclohydrolase I activity in rat and human tissues using radioimmunoassay of neopterin (1986), Anal. Biochem., 154, 361-366.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.16 0.06
-
 GTP
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.16 Homo sapiens
-
-
-
3.5.4.16 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.16 brain
-
 Homo sapiens
-
3.5.4.16 brain
-
 Rattus norvegicus
-
3.5.4.16 liver
-
 Homo sapiens
-
3.5.4.16 liver
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
3.5.4.16 -80°C, 6 months, stable Homo sapiens
3.5.4.16 -80°C, 6 months, stable Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.16 GTP + H2O
-
 Homo sapiens formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O
-
 Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.4.16 22
-
 no significant loss of activity after 5 h Homo sapiens
3.5.4.16 22
-
 no significant loss of activity after 5 h Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.16 7.8
-
-
 Rattus norvegicus