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Literature summary extracted from

  • Schoedon, G.; Curtis, H.C.; Niederwieser, A.
    Localization of GTP cyclohydrolase I in human peripheral blood smears using a specific monoclonal antibody and an immune-alkaline phosphatase labeling technique (1987), Biochem. Biophys. Res. Commun., 148, 1232-1236.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.16 GTP + H2O Homo sapiens first step in biosynthesis of tetrahydrobiopterin, BH4 formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.16 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.16 blood
-
 Homo sapiens
-
3.5.4.16 granulocyte
-
 Homo sapiens
-
3.5.4.16 lymphocyte
-
 Homo sapiens
-
3.5.4.16 monocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.16 GTP + H2O
-
 Homo sapiens formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
3.5.4.16 GTP + H2O first step in biosynthesis of tetrahydrobiopterin, BH4 Homo sapiens formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?