BRENDA - Enzyme Database

Arginine deiminase from Mycoplasma arthritidis. Structure-activity relationships among substrates and competitive inhibitors

Smith, D.W.; Ganaway, R.L.; Fahrney, D.E.; J. Biol. Chem. 253, 6016-6020 (1978)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.3.6
agmatine
-
Mycoplasma arthritidis
3.5.3.6
aminoguanidine
-
Mycoplasma arthritidis
3.5.3.6
arcaine
-
Mycoplasma arthritidis
3.5.3.6
Ethylguanidine
-
Mycoplasma arthritidis
3.5.3.6
formylguanidine
-
Mycoplasma arthritidis
3.5.3.6
guanidine
-
Mycoplasma arthritidis
3.5.3.6
L-alpha-aminobutyrate
-
Mycoplasma arthritidis
3.5.3.6
L-homoarginine
-
Mycoplasma arthritidis
3.5.3.6
Lys
-
Mycoplasma arthritidis
3.5.3.6
methylguanidine
-
Mycoplasma arthritidis
3.5.3.6
nitroguanidine
-
Mycoplasma arthritidis
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.5.3.6
0.004
-
L-Arg
-
Mycoplasma arthritidis
3.5.3.6
0.044
-
L-canavanine
-
Mycoplasma arthritidis
3.5.3.6
1.2
-
Nalpha-methyl-L-Arg
-
Mycoplasma arthritidis
3.5.3.6
4.7
-
L-homoarginine
-
Mycoplasma arthritidis
3.5.3.6
10
-
D-Arg
-
Mycoplasma arthritidis
3.5.3.6
11
-
guanidine
-
Mycoplasma arthritidis
3.5.3.6
16
-
L-argininic acid
-
Mycoplasma arthritidis
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.3.6
Mycoplasma arthritidis
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.3.6
D-Arg + H2O
0.38% of the activity with L-Arg
209453
Mycoplasma arthritidis
D-citrulline + NH3
-
-
-
?
3.5.3.6
L-Arg + H2O
-
209453
Mycoplasma arthritidis
L-citrulline + NH3
-
209453
Mycoplasma arthritidis
ir
3.5.3.6
L-argininic acid + H2O
0.032% of the activity with L-Arg
209453
Mycoplasma arthritidis
(2S)-5-[(aminocarbonyl)amino]-2-hydroxypentanoic acid + NH3
-
-
-
?
3.5.3.6
L-canavanine + H2O
2.3% of the activity with L-Arg
209453
Mycoplasma arthritidis
(2S)-2-amino-4-[[(aminocarbonyl)amino]oxy]butanoic acid + NH3
-
-
-
?
3.5.3.6
L-homoarginine + H2O
0.05% of the activity with L-Arg
209453
Mycoplasma arthritidis
(2S)-2-amino-6-[(aminocarbonyl)amino]hexanoic acid + NH3
-
-
-
?
3.5.3.6
Nalpha-methyl-L-Arg + H2O
0.75% of the activity with L-Arg
209453
Mycoplasma arthritidis
Nalpha-methyl-L-citrulline + NH3
-
-
-
?
Turnover Number [1/s]
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
3.5.3.6
additional information
-
additional information
-
Mycoplasma arthritidis
3.5.3.6
29
-
L-Arg
-
Mycoplasma arthritidis
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.3.6
agmatine
-
Mycoplasma arthritidis
3.5.3.6
aminoguanidine
-
Mycoplasma arthritidis
3.5.3.6
arcaine
-
Mycoplasma arthritidis
3.5.3.6
Ethylguanidine
-
Mycoplasma arthritidis
3.5.3.6
formylguanidine
-
Mycoplasma arthritidis
3.5.3.6
guanidine
-
Mycoplasma arthritidis
3.5.3.6
L-alpha-aminobutyrate
-
Mycoplasma arthritidis
3.5.3.6
L-homoarginine
-
Mycoplasma arthritidis
3.5.3.6
Lys
-
Mycoplasma arthritidis
3.5.3.6
methylguanidine
-
Mycoplasma arthritidis
3.5.3.6
nitroguanidine
-
Mycoplasma arthritidis
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.5.3.6
0.004
-
L-Arg
-
Mycoplasma arthritidis
3.5.3.6
0.044
-
L-canavanine
-
Mycoplasma arthritidis
3.5.3.6
1.2
-
Nalpha-methyl-L-Arg
-
Mycoplasma arthritidis
3.5.3.6
4.7
-
L-homoarginine
-
Mycoplasma arthritidis
3.5.3.6
10
-
D-Arg
-
Mycoplasma arthritidis
3.5.3.6
11
-
guanidine
-
Mycoplasma arthritidis
3.5.3.6
16
-
L-argininic acid
-
Mycoplasma arthritidis
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.3.6
D-Arg + H2O
0.38% of the activity with L-Arg
209453
Mycoplasma arthritidis
D-citrulline + NH3
-
-
-
?
3.5.3.6
L-Arg + H2O
-
209453
Mycoplasma arthritidis
L-citrulline + NH3
-
209453
Mycoplasma arthritidis
ir
3.5.3.6
L-argininic acid + H2O
0.032% of the activity with L-Arg
209453
Mycoplasma arthritidis
(2S)-5-[(aminocarbonyl)amino]-2-hydroxypentanoic acid + NH3
-
-
-
?
3.5.3.6
L-canavanine + H2O
2.3% of the activity with L-Arg
209453
Mycoplasma arthritidis
(2S)-2-amino-4-[[(aminocarbonyl)amino]oxy]butanoic acid + NH3
-
-
-
?
3.5.3.6
L-homoarginine + H2O
0.05% of the activity with L-Arg
209453
Mycoplasma arthritidis
(2S)-2-amino-6-[(aminocarbonyl)amino]hexanoic acid + NH3
-
-
-
?
3.5.3.6
Nalpha-methyl-L-Arg + H2O
0.75% of the activity with L-Arg
209453
Mycoplasma arthritidis
Nalpha-methyl-L-citrulline + NH3
-
-
-
?
Turnover Number [1/s] (protein specific)
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
3.5.3.6
additional information
-
additional information
-
Mycoplasma arthritidis
3.5.3.6
29
-
L-Arg
-
Mycoplasma arthritidis