Literature summary extracted from

Smith, D.W.; Ganaway, R.L.; Fahrney, D.E.
Arginine deiminase from Mycoplasma arthritidis. Structure-activity relationships among substrates and competitive inhibitors (1978), J. Biol. Chem., 253, 6016-6020.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.5.3.6	agmatine	-	Mycoplasma arthritidis
3.5.3.6	aminoguanidine	-	Mycoplasma arthritidis
3.5.3.6	arcaine	-	Mycoplasma arthritidis
3.5.3.6	Ethylguanidine	-	Mycoplasma arthritidis
3.5.3.6	formylguanidine	-	Mycoplasma arthritidis
3.5.3.6	guanidine	-	Mycoplasma arthritidis
3.5.3.6	L-alpha-aminobutyrate	-	Mycoplasma arthritidis
3.5.3.6	L-homoarginine	-	Mycoplasma arthritidis
3.5.3.6	Lys	-	Mycoplasma arthritidis
3.5.3.6	methylguanidine	-	Mycoplasma arthritidis
3.5.3.6	nitroguanidine	-	Mycoplasma arthritidis

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.5.3.6	0.004	-	L-Arg	-	Mycoplasma arthritidis
3.5.3.6	0.044	-	L-canavanine	-	Mycoplasma arthritidis
3.5.3.6	1.2	-	Nalpha-methyl-L-Arg	-	Mycoplasma arthritidis
3.5.3.6	4.7	-	L-homoarginine	-	Mycoplasma arthritidis
3.5.3.6	10	-	D-Arg	-	Mycoplasma arthritidis
3.5.3.6	11	-	guanidine	-	Mycoplasma arthritidis
3.5.3.6	16	-	L-argininic acid	-	Mycoplasma arthritidis

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.3.6	Mycoplasma arthritidis	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.3.6	D-Arg + H2O	0.38% of the activity with L-Arg	Mycoplasma arthritidis	D-citrulline + NH3	-	?
3.5.3.6	guanidine + H2O	-	Mycoplasma arthritidis	urea + NH3	-	?
3.5.3.6	L-Arg + H2O	-	Mycoplasma arthritidis	L-citrulline + NH3	-	ir
3.5.3.6	L-argininic acid + H2O	0.032% of the activity with L-Arg	Mycoplasma arthritidis	(2S)-5-[(aminocarbonyl)amino]-2-hydroxypentanoic acid + NH3	-	?
3.5.3.6	L-canavanine + H2O	2.3% of the activity with L-Arg	Mycoplasma arthritidis	(2S)-2-amino-4-[[(aminocarbonyl)amino]oxy]butanoic acid + NH3	-	?
3.5.3.6	L-homoarginine + H2O	0.05% of the activity with L-Arg	Mycoplasma arthritidis	(2S)-2-amino-6-[(aminocarbonyl)amino]hexanoic acid + NH3	-	?
3.5.3.6	Nalpha-methyl-L-Arg + H2O	0.75% of the activity with L-Arg	Mycoplasma arthritidis	Nalpha-methyl-L-citrulline + NH3	-	?

Turnover Number [1/s]

EC Number	Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
3.5.3.6	additional information	-	additional information	-	Mycoplasma arthritidis
3.5.3.6	29	-	L-Arg	-	Mycoplasma arthritidis

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Release 2023.1 (January 2023)