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Literature summary extracted from

  • Lamensa, K.W.E.; Moscarello, M.A.
    Deimination of human myelin basic protein by a peptidylarginine deiminase from bovine brain (1993), J. Neurochem., 61, 987-996.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.3.15 0.78
-
 benzoyl-Arg ethyl ester Km-value of the high activity binding site Bos taurus
3.5.3.15 11.2
-
 benzoylarginine ethyl ester Km-value of the low activity binding site Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.3.15 Ca2+ required Bos taurus
3.5.3.15 Ca2+ maximal activity at 2 mM Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.15 protein L-Arg + H2O Bos taurus C-1, the most unmodified of the components of myelin basic protein, is an excellent substrate for the enzyme, thereby confirming that the origin of the citrulline in myelin basic protein arises by the action of this enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.15 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.3.15 partial Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.15 brain
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.3.15 1.1
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.15 benzoyl-Arg ethyl ester + H2O
-
 Bos taurus benzoyl-citrulline ethyl ester + NH3
-
 ?
3.5.3.15 Nalpha-benzoyl-L-arginine ethyl ester + H2O
-
 Bos taurus Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
 ?
3.5.3.15 Polyarginine + H2O
-
 Bos taurus ?
-
 ?
3.5.3.15 protein L-Arg + H2O human myelin basic protein Bos taurus protein L-citrulline + NH3
-
 ?
3.5.3.15 protein L-Arg + H2O no activity with histones Bos taurus protein L-citrulline + NH3
-
 ?
3.5.3.15 protein L-Arg + H2O C-1, the most unmodified of the components of myelin basic protein, is an excellent substrate for the enzyme, thereby confirming that the origin of the citrulline in myelin basic protein arises by the action of this enzyme Bos taurus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.3.15 50
-
-
 Bos taurus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.5.3.15 20 60
-
 Bos taurus