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Literature summary extracted from

  • Fujisaki, M.; Sugawara, K.
    Properties of peptidylarginine deiminase from the epidermis of newborn rats (1981), J. Biochem., 89, 257-263.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.3.15 dithiothreitol enhances activity, maximal activation at 2 mM Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.15 monoiodoacetate
-
 Rattus norvegicus
3.5.3.15 PCMB
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.3.15 Ca2+ required Rattus norvegicus
3.5.3.15 Ca2+ maximal activity in presence of 8-10 mM CaCl2 Rattus norvegicus
3.5.3.15 Ca2+ 10 mM, 11% of the activity with Ca2+ Rattus norvegicus
3.5.3.15 Sr2+ 10 mM, 85% of the activity with Ca2+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.3.15 48000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.15 protein L-Arg + H2O Rattus norvegicus citrullyl residues in the membranous protein of horny cells of the epidermis of newborn rat are formed by the action of epidermal peptidylarginine deiminase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.15 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.15 epidermis
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.3.15 0.00077
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.15 benzoyl-Gly-L-Arg + H2O
-
 Rattus norvegicus benzoyl-Gly-L-citrulline + NH3
-
 ir
3.5.3.15 benzoyl-L-Arg + H2O
-
 Rattus norvegicus benzoyl-L-citrulline + NH3
-
 ir
3.5.3.15 benzoyl-L-Arg-NH2 + H2O
-
 Rattus norvegicus benzoyl-L-citrullineamide + NH3
-
 ir
3.5.3.15 L-Arg + H2O negligible action Rattus norvegicus L-citrulline + NH3
-
 ?
3.5.3.15 protein L-Arg + H2O citrullyl residues in the membranous protein of horny cells of the epidermis of newborn rat are formed by the action of epidermal peptidylarginine deiminase Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.3.15 50
-
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.3.15 7.5
-
-
 Rattus norvegicus