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Literature summary extracted from

  • Griffith, O.W.; Meister, A.
    Interaction of 5-oxo-L-prolinase with nucleoside triphosphates. Evidence suggesting substrate-dependent conformational change (1982), J. Biol. Chem., 257, 4392-4397.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.5.2.9 unstable in absence of 5-oxo-L-proline Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.9 0.03
-
 ATP without 5-oxoproline Rattus norvegicus
3.5.2.9 0.16
-
 5-oxoproline initial Km in presence of GTP Rattus norvegicus
3.5.2.9 0.17
-
 UTP without 5-oxoproline Rattus norvegicus
3.5.2.9 0.17
-
 ITP without 5-oxoproline Rattus norvegicus
3.5.2.9 0.18
-
 5-oxoproline initial Km in presence of ITP Rattus norvegicus
3.5.2.9 0.2
-
 5-oxoproline initial Km in presence of UTP Rattus norvegicus
3.5.2.9 0.41
-
 5-oxoproline in presence of ATP Rattus norvegicus
3.5.2.9 0.41
-
 ITP 5-oxoproline added Rattus norvegicus
3.5.2.9 0.42
-
 ATP 5-oxoproline added Rattus norvegicus
3.5.2.9 0.5
-
 5-oxoproline final Km in presence of UTP Rattus norvegicus
3.5.2.9 0.57
-
 5-oxoproline final Km in presence of GTP Rattus norvegicus
3.5.2.9 0.58
-
 5-oxoproline final Km in presence of ITP Rattus norvegicus
3.5.2.9 1.11
-
 UTP 5-oxoproline added Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.2.9 5-oxo-L-proline + H2O + ATP Rattus norvegicus
-
 L-glutamate + ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.9 Rattus norvegicus
-
 rat
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.9 2-imidazolidone-4-carboxylate + ATP + H2O promotes enzymatic hydrolysis of ATP but is not itself hydrolyzed Rattus norvegicus 2-imidazolidone + ADP + phosphate
-
 ?
3.5.2.9 2-piperidone-6-carboxylate + ATP + H2O
-
 Rattus norvegicus 2-aminoadipate + phosphate + ADP
-
 ?
3.5.2.9 3-methyl-5-oxoproline + H2O
-
 Rattus norvegicus 2-amino-3-methylpentanedioic acid
-
 ?
3.5.2.9 4-methyl-5-oxoproline + H2O
-
 Rattus norvegicus 2-amino-4-methylpentanedioic acid
-
 ?
3.5.2.9 5-oxo-L-proline + H2O + ATP
-
 Rattus norvegicus L-glutamate + ADP + phosphate
-
 ?
3.5.2.9 ATP + H2O
-
 Rattus norvegicus ?
-
 ?
3.5.2.9 GTP + H2O
-
 Rattus norvegicus ?
-
 ?
3.5.2.9 ITP + H2O
-
 Rattus norvegicus ?
-
 ?
3.5.2.9 additional information 5-oxo-D-proline, 2-pyrrolidone-4-carboxylate, N-methyl-5-oxo-L-proline and N-acetyl-L-alanine are no substrates Rattus norvegicus ?
-
 ?
3.5.2.9 UTP + H2O
-
 Rattus norvegicus ?
-
 ?