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Literature summary extracted from

  • Hedberg, M.; Lindqvist, L.; Tuner, K.; Nord, C.E.
    Effect of beta-lactamase inhibitors on beta-lactamase from anaerobic bacteria (1992), Eur. J. Clin. Microbiol. Infect. Dis., 11, 1100-1104.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 clavulanic acid after 20min 20% remaining activity; inactivation in 20 min Bacteroides uniformis
3.5.2.6 clavulanic acid after 20 min 55% remaining activity; inactivation in 20 min Clostridium butyricum
3.5.2.6 clavulanic acid after 20 min 90% remaining activity; inactivation in 20 min Fusobacterium nucleatum
3.5.2.6 Sulbactam after 20min 10% remaining activity Bacteroides uniformis
3.5.2.6 Sulbactam after 20 min 65% remaining activity Clostridium butyricum
3.5.2.6 Sulbactam after 20 min 65% remaining activity Fusobacterium nucleatum
3.5.2.6 tazobactam after 1 h 60% remaining activity Bacteroides uniformis
3.5.2.6 tazobactam after 1 h 90% remaining activity; inactivation after 1-2 h Clostridium butyricum
3.5.2.6 tazobactam after 1 h 20% remaining activity; inactivation after 1-2 h Fusobacterium nucleatum

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Bacteroides uniformis
-
-
-
3.5.2.6 Bacteroides uniformis B371
-
-
-
3.5.2.6 Clostridium butyricum
-
-
-
3.5.2.6 Clostridium butyricum NBL3
-
-
-
3.5.2.6 Fusobacterium nucleatum
-
-
-
3.5.2.6 Fusobacterium nucleatum F21
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.6
-
 Clostridium butyricum
3.5.2.6
-
 Fusobacterium nucleatum
3.5.2.6
-
 Bacteroides uniformis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 nitrocefin + H2O
-
 Clostridium butyricum (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Fusobacterium nucleatum (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Bacteroides uniformis (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Fusobacterium nucleatum F21 (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Bacteroides uniformis B371 (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Clostridium butyricum NBL3 (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?