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Literature summary extracted from

  • Peduzzi, J.; Farzaneh, S.; Reynaud, A.; Barthelemy, M.; Labia, R.
    Characterization and amino acid sequence analysis of a new oxyimino cephalosporin-hydrolysing class A beta-lactamase from Serratia fonticolc CUV (1997), Biochim. Biophys. Acta, 1341, 58-70.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 clavulanic acid
-
 Serratia fonticola
3.5.2.6 Sulbactam
-
 Serratia fonticola
3.5.2.6 tazobactam
-
 Serratia fonticola

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.01
-
 cefoperazone
-
 Serratia fonticola
3.5.2.6 0.015
-
 mezlocillin
-
 Serratia fonticola
3.5.2.6 0.02
-
 cefuroxime
-
 Serratia fonticola
3.5.2.6 0.023
-
 benzylpenicillin
-
 Serratia fonticola
3.5.2.6 0.023
-
 piperacillin
-
 Serratia fonticola
3.5.2.6 0.028
-
 ceftriazone
-
 Serratia fonticola
3.5.2.6 0.031
-
 ticarcillin
-
 Serratia fonticola
3.5.2.6 0.035
-
 amoxycillin
-
 Serratia fonticola
3.5.2.6 0.04
-
 carbenicillin
-
 Serratia fonticola
3.5.2.6 0.041
-
 aztreonam
-
 Serratia fonticola
3.5.2.6 0.042
-
 Oxacillin
-
 Serratia fonticola
3.5.2.6 0.043
-
 Cloxacillin
-
 Serratia fonticola
3.5.2.6 0.055
-
 cefotiam
-
 Serratia fonticola
3.5.2.6 0.08
-
 cefotaxime
-
 Serratia fonticola
3.5.2.6 0.175
-
 cephalothin
-
 Serratia fonticola
3.5.2.6 0.175
-
 cephaloridine
-
 Serratia fonticola
3.5.2.6 0.2
-
 cefamandole
-
 Serratia fonticola
3.5.2.6 0.43
-
 cefepime
-
 Serratia fonticola
3.5.2.6 0.44
-
 cefpirome
-
 Serratia fonticola
3.5.2.6 0.5
-
 ceftazidime
-
 Serratia fonticola

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.2.6 28100
-
 SDS-PAGE Serratia fonticola
3.5.2.6 28100
-
 isoenzyme II Serratia fonticola
3.5.2.6 28400
-
 SDS-PAGE Serratia fonticola
3.5.2.6 28400
-
 isoenzyme I Serratia fonticola

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Serratia fonticola
-
-
-
3.5.2.6 Serratia fonticola CUV
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.2.6 1650
-
-
 Serratia fonticola

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 amoxicillin + H2O
-
 Serratia fonticola (2R,4S)-2-[(R)-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 amoxicillin + H2O
-
 Serratia fonticola CUV (2R,4S)-2-[(R)-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 aztreonam + H2O
-
 Serratia fonticola [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
-
 ?
3.5.2.6 aztreonam + H2O
-
 Serratia fonticola CUV [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
-
 ?
3.5.2.6 benzylpenicillin + H2O
-
 Serratia fonticola (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 benzylpenicillin + H2O
-
 Serratia fonticola CUV (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 carbenicillin + H2O
-
 Serratia fonticola (2R,4S)-2-{(R)-carboxy[2-carboxy(phenyl)acetamido]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cefamandole + H2O
-
 Serratia fonticola (2R)-2-[(R)-carboxy{[(2R)-2-hydroxy-2-phenylacetyl]amino}methyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefepime + H2O
-
 Serratia fonticola (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cefoperazone + H2O
-
 Serratia fonticola (2R)-2-[(R)-carboxy{[(2S)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino}methyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefotaxime + H2O
-
 Serratia fonticola (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefotiam + H2O
-
 Serratia fonticola (2R)-2-[(R)-[2-(2-amino-1,3-thiazol-4-yl)acetamido](carboxy)methyl]-5-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefpirome + H2O
-
 Serratia fonticola (2S)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-[(6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 ceftazidime + H2O
-
 Serratia fonticola (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 ceftriaxone + H2O
-
 Serratia fonticola (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefuroxime + H2O
-
 Serratia fonticola (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephaloridine + H2O
-
 Serratia fonticola (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephaloridine + H2O
-
 Serratia fonticola CUV (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephalothin + H2O
-
 Serratia fonticola (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalothin + H2O
-
 Serratia fonticola CUV (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cloxacillin + H2O
-
 Serratia fonticola (2R,4S)-2-[(R)-carboxy{[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 mezlocillin + H2O
-
 Serratia fonticola (2R,4S)-2-[(R)-carboxy{[(2R)-2-{[3-(methanesulfonyl)-2-oxoimidazolidine-1-carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O
-
 Serratia fonticola (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 piperacillin + H2O
-
 Serratia fonticola (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ticarcillin + H2O
-
 Serratia fonticola (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.2.6 30
-
 ceftazidime
-
 Serratia fonticola
3.5.2.6 38
-
 aztreonam
-
 Serratia fonticola
3.5.2.6 70
-
 cefoperazone
-
 Serratia fonticola
3.5.2.6 90
-
 Cloxacillin
-
 Serratia fonticola
3.5.2.6 100
-
 carbenicillin
-
 Serratia fonticola
3.5.2.6 105
-
 Oxacillin
-
 Serratia fonticola
3.5.2.6 115
-
 ticarcillin
-
 Serratia fonticola
3.5.2.6 225
-
 cefepime
-
 Serratia fonticola
3.5.2.6 255
-
 piperacillin
-
 Serratia fonticola
3.5.2.6 255
-
 mezlocillin
-
 Serratia fonticola
3.5.2.6 460
-
 amoxycillin
-
 Serratia fonticola
3.5.2.6 540
-
 cefuroxime
-
 Serratia fonticola
3.5.2.6 620
-
 ceftriazone
-
 Serratia fonticola
3.5.2.6 745
-
 cefpirome
-
 Serratia fonticola
3.5.2.6 770
-
 benzylpenicillin
-
 Serratia fonticola
3.5.2.6 920
-
 cefotaxime
-
 Serratia fonticola
3.5.2.6 945
-
 cefotiam
-
 Serratia fonticola
3.5.2.6 2530
-
 cephaloridine
-
 Serratia fonticola
3.5.2.6 6110
-
 cefamandole
-
 Serratia fonticola
3.5.2.6 7150
-
 cephalothin
-
 Serratia fonticola