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Literature summary extracted from

  • Sunaga, T.; Akiba, T.; Horikoshi, K.
    Separation and properties of penicillinase of an alkalophilic Bacillus (1979), Agric. Biol. Chem., 43, 477-480.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 Ag+
-
 Bacillus sp. (in: Bacteria)
3.5.2.6 Hg2+
-
 Bacillus sp. (in: Bacteria)
3.5.2.6 Urea
-
 Bacillus sp. (in: Bacteria)

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.041
-
 penicillin G penicillinase II Bacillus sp. (in: Bacteria)
3.5.2.6 0.105
-
 penicillin G penicillinase I Bacillus sp. (in: Bacteria)
3.5.2.6 0.108
-
 cephaloridine penicillinase II Bacillus sp. (in: Bacteria)
3.5.2.6 0.114
-
 ampicillin penicillinase II Bacillus sp. (in: Bacteria)
3.5.2.6 0.131
-
 ampicillin penicillinase I Bacillus sp. (in: Bacteria)
3.5.2.6 0.134
-
 cephaloridine penicillinase I Bacillus sp. (in: Bacteria)
3.5.2.6 0.135
-
 carbenicillin penicillinase I Bacillus sp. (in: Bacteria)
3.5.2.6 0.15
-
 carbenicillin penicillinase II Bacillus sp. (in: Bacteria)
3.5.2.6 0.155
-
 2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid penicillinase I Bacillus sp. (in: Bacteria)
3.5.2.6 0.159
-
 2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid penicillinase II Bacillus sp. (in: Bacteria)
3.5.2.6 0.19
-
 Oxacillin penicillinase I Bacillus sp. (in: Bacteria)
3.5.2.6 0.2
-
 Oxacillin penicillinase II Bacillus sp. (in: Bacteria)
3.5.2.6 0.3
-
 cephalothin penicillinase I Bacillus sp. (in: Bacteria)
3.5.2.6 0.356
-
 cephalothin penicillinase II Bacillus sp. (in: Bacteria)

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.2.6 Zn2+ penicillase I Bacillus sp. (in: Bacteria)

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.2.6 12500
-
 penicillinase II, gel filtration Bacillus sp. (in: Bacteria)
3.5.2.6 40000
-
 penicillinase I Bacillus sp. (in: Bacteria)

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Bacillus sp. (in: Bacteria)
-
-
-
3.5.2.6 Bacillus sp. (in: Bacteria) No. 170
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 ampicillin + H2O
-
 Bacillus sp. (in: Bacteria) (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ampicillin + H2O
-
 Bacillus sp. (in: Bacteria) No. 170 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 carbenicillin + H2O
-
 Bacillus sp. (in: Bacteria) (2R,4S)-2-{(R)-carboxy[2-carboxy(phenyl)acetamido]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 carbenicillin + H2O
-
 Bacillus sp. (in: Bacteria) No. 170 (2R,4S)-2-{(R)-carboxy[2-carboxy(phenyl)acetamido]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cephaloridine + H2O
-
 Bacillus sp. (in: Bacteria) (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephaloridine + H2O
-
 Bacillus sp. (in: Bacteria) No. 170 (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephalothin + H2O
-
 Bacillus sp. (in: Bacteria) (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalothin + H2O
-
 Bacillus sp. (in: Bacteria) No. 170 (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cloxacillin + H2O
-
 Bacillus sp. (in: Bacteria) (2R,4S)-2-[(R)-carboxy{[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cloxacillin + H2O
-
 Bacillus sp. (in: Bacteria) No. 170 (2R,4S)-2-[(R)-carboxy{[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O
-
 Bacillus sp. (in: Bacteria) (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 penicillin G + H2O
-
 Bacillus sp. (in: Bacteria) (2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 penicillinase I, II different in substrate specificity, pH and temperature stability, molecular weight Bacillus sp. (in: Bacteria)

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.2.6 40
-
 stable up to Bacillus sp. (in: Bacteria)

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.2.6 7
-
-
 Bacillus sp. (in: Bacteria)

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.5.2.6 6 8 penicillinase I Bacillus sp. (in: Bacteria)
3.5.2.6 9 10 penicillinase II Bacillus sp. (in: Bacteria)