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Literature summary extracted from
- Properties of cephalosporinase from Proteus morganii (1981), J. Antibiot., 11, 1469-1475.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.2.6 | ampicillin | - |
Morganella morganii |  |
| 3.5.2.6 | carbenicillin | - |
Morganella morganii | |
| 3.5.2.6 | cefmenoxime | - |
Morganella morganii | |
| 3.5.2.6 | cefmetazole | - |
Morganella morganii | |
| 3.5.2.6 | cefotaxime | - |
Morganella morganii | |
| 3.5.2.6 | cefoxitin | - |
Morganella morganii | |
| 3.5.2.6 | ceftizoxime | - |
Morganella morganii | |
| 3.5.2.6 | cefuroxime | - |
Morganella morganii | |
| 3.5.2.6 | Cloxacillin | - |
Morganella morganii | |
| 3.5.2.6 | Hg2+ | - |
Morganella morganii | |
| 3.5.2.6 | I2 | - |
Morganella morganii | |
| 3.5.2.6 | moxalactam | - |
Morganella morganii | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.2.6 | 0.006 | - |
cephalexin | - |
Morganella morganii | |
| 3.5.2.6 | 0.019 | - |
cefotiam | - |
Morganella morganii | |
| 3.5.2.6 | 0.02 | - |
cephalothin | - |
Morganella morganii | |
| 3.5.2.6 | 0.026 | - |
benzylpenicillin | - |
Morganella morganii | |
| 3.5.2.6 | 0.033 | - |
cefamandole | - |
Morganella morganii | |
| 3.5.2.6 | 0.083 | - |
cefazolin | - |
Morganella morganii | |
| 3.5.2.6 | 0.167 | - |
cefoperazone | - |
Morganella morganii | |
| 3.5.2.6 | 0.5 | - |
cephaloridine | - |
Morganella morganii | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.5.2.6 | 41000 | - |
SDS-PAGE | Morganella morganii |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.2.6 | benzylpenicillin + H2O | Morganella morganii | - |
(2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | benzylpenicillin + H2O | Morganella morganii GN5407 | - |
(2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cefamandole + H2O | Morganella morganii | - |
(2R)-2-[(R)-carboxy{[(2R)-2-hydroxy-2-phenylacetyl]amino}methyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cefazolin + H2O | Morganella morganii | - |
(2R)-2-[(R)-carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cefotiam + H2O | Morganella morganii | - |
(2R)-2-[(R)-[2-(2-amino-1,3-thiazol-4-yl)acetamido](carboxy)methyl]-5-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cephalexin + H2O | Morganella morganii | - |
(2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cephalexin + H2O | Morganella morganii GN5407 | - |
(2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cephaloridine + H2O | Morganella morganii | - |
(2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
| 3.5.2.6 | cephaloridine + H2O | Morganella morganii GN5407 | - |
(2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
| 3.5.2.6 | cephalothin + H2O | Morganella morganii | - |
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cephalothin + H2O | Morganella morganii GN5407 | - |
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.2.6 | Morganella morganii | - |
- |
- |
| 3.5.2.6 | Morganella morganii GN5407 | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.2.6 | - |
Morganella morganii |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.2.6 | benzylpenicillin + H2O | - |
Morganella morganii | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | benzylpenicillin + H2O | - |
Morganella morganii GN5407 | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cefamandole + H2O | - |
Morganella morganii | (2R)-2-[(R)-carboxy{[(2R)-2-hydroxy-2-phenylacetyl]amino}methyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cefazolin + H2O | - |
Morganella morganii | (2R)-2-[(R)-carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cefoperazone + H2O | - |
Morganella morganii | (2R)-2-[(R)-carboxy{[(2S)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino}methyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cefoperazone + H2O | - |
Morganella morganii GN5407 | (2R)-2-[(R)-carboxy{[(2S)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino}methyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cefotiam + H2O | - |
Morganella morganii | (2R)-2-[(R)-[2-(2-amino-1,3-thiazol-4-yl)acetamido](carboxy)methyl]-5-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cephalexin + H2O | - |
Morganella morganii | (2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cephalexin + H2O | - |
Morganella morganii GN5407 | (2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cephaloridine + H2O | - |
Morganella morganii | (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
| 3.5.2.6 | cephaloridine + H2O | - |
Morganella morganii GN5407 | (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
| 3.5.2.6 | cephalothin + H2O | - |
Morganella morganii | (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
| 3.5.2.6 | cephalothin + H2O | - |
Morganella morganii GN5407 | (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.2.6 | 40 | - |
- |
Morganella morganii |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.2.6 | 8.5 | - |
- |
Morganella morganii |
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