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Literature summary extracted from

  • Serrano, A.E.; Nagayama, F.
    Inhibition studies on liver arylformamidases of rainbow trout and cattle (1991), Comp. Biochem. Physiol. B, 99, 281-285.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.9 arginine 30% activation at 20 mM Bos taurus
3.5.1.9 ascorbate 57% activation at 100 mM Oncorhynchus mykiss
3.5.1.9 L-tryptophan activation from 5-20 mM Bos taurus
3.5.1.9 lysine 30% activation at 20 mM Bos taurus
3.5.1.9 methionine 20% activation at 20 mM Bos taurus

General Stability

EC Number General Stability Organism
3.5.1.9 ionic strength affects enzyme activity Bos taurus
3.5.1.9 ionic strength affects enzyme activity Oncorhynchus mykiss

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.9 3-hydroxy-DL-kynurenine 50% inhibition at 0.2 mM, Ki: 8 mM Oncorhynchus mykiss
3.5.1.9 anthranilic acid 9% inhibition at 0.5-1 mM Bos taurus
3.5.1.9 anthranilic acid 29% inhibition at 1-2 mM Oncorhynchus mykiss
3.5.1.9 ascorbate 50% inhibition at 10 mM Bos taurus
3.5.1.9 Ba2+ strong inhibition at 1 mM Bos taurus
3.5.1.9 Co2+ moderate inhibition at 1 mM Bos taurus
3.5.1.9 Co2+ moderate inhibition at 1 mM Oncorhynchus mykiss
3.5.1.9 Cu2+ moderate inhibition at 1 mM Oncorhynchus mykiss
3.5.1.9 Hg2+ moderate inhibition at 1 mM Bos taurus
3.5.1.9 Hg2+ strong inhibition at 1 mM Oncorhynchus mykiss
3.5.1.9 isoleucine 19% inhibition at 20 mM Oncorhynchus mykiss
3.5.1.9 L-kynurenine marked inhibition above 0.1 mM Bos taurus
3.5.1.9 L-kynurenine competitive inhibition, Ki: 0.26 mM Oncorhynchus mykiss
3.5.1.9 L-tryptophan non-competitive inhibition, Ki: 5.24 mM Oncorhynchus mykiss
3.5.1.9 methionine 20% inhibition at 20 mM Oncorhynchus mykiss
3.5.1.9 Mg2+ moderate inhibition at 1 mM Bos taurus
3.5.1.9 Mn2+ strong inhibition at 1 mM Bos taurus
3.5.1.9 Mn2+ strong inhibition at 1 mM Oncorhynchus mykiss
3.5.1.9 Na-bisulfite 50% inhibition at 0.18 mM Bos taurus
3.5.1.9 Na-bisulfite 50% inhibition at 0.32 mM Oncorhynchus mykiss
3.5.1.9 NaHSO3 50% inhibition at 0.18 mM Bos taurus
3.5.1.9 NaHSO3 50% inhibition at 0.32 mM Oncorhynchus mykiss
3.5.1.9 phenylalanine slight inhibition at 20 mM Bos taurus
3.5.1.9 phenylalanine slight inhibition at 20 mM Oncorhynchus mykiss
3.5.1.9 threonine 19% inhibition at 20 mM Oncorhynchus mykiss
3.5.1.9 valine slight inhibition at 20 mM Bos taurus
3.5.1.9 Zn2+ moderate inhibition at 1 mM Bos taurus
3.5.1.9 Zn2+ strong inhibition at 1 mM Oncorhynchus mykiss

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.9 N-formyl-L-kynurenine + H2O Bos taurus
-
 L-kynurenine + formate
-
 ?
3.5.1.9 N-formyl-L-kynurenine + H2O Oncorhynchus mykiss
-
 L-kynurenine + formate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.9 Bos taurus
-
-
-
3.5.1.9 Oncorhynchus mykiss
-
 rainbow trout
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.9 liver
-
 Bos taurus
-
3.5.1.9 liver
-
 Oncorhynchus mykiss
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.9 N-formyl-L-kynurenine + H2O
-
 Bos taurus L-kynurenine + formate
-
 ?
3.5.1.9 N-formyl-L-kynurenine + H2O
-
 Oncorhynchus mykiss L-kynurenine + formate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.9 0.18
-
 NaHSO3
-
 Bos taurus
3.5.1.9 0.18
-
 Na-bisulfite
-
 Bos taurus
3.5.1.9 0.32
-
 NaHSO3
-
 Oncorhynchus mykiss
3.5.1.9 5.24
-
 L-tryptophan non-competitive inhibition Oncorhynchus mykiss
3.5.1.9 8
-
 3-hydroxy-DL-kynurenine
-
 Oncorhynchus mykiss
3.5.1.9 10
-
 ascorbate
-
 Bos taurus