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Literature summary extracted from

  • Imada, A.; Igarski, S.
    Extracellular asparaginase-glutaminase of Tilachlidium humicola (1973), J. Takeda Res. Lab., 32, 140-151.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.38 Cu2+ slight inhibition at 1 mM Tilachlidium humicola
3.5.1.38 D-asparagine mixed type of competitive and non-competitive inhibition, Ki: 7.2-8.4 mM Tilachlidium humicola
3.5.1.38 EDTA slight inhibition at 8 mM Tilachlidium humicola
3.5.1.38 Hg2+ slight inhibition at 1 mM Tilachlidium humicola
3.5.1.38 KCN slight inhibition at 8 mM Tilachlidium humicola
3.5.1.38 NaAsO2 90% inhibition at 8 mM Tilachlidium humicola
3.5.1.38 NaF slight inhibition at 8 mM Tilachlidium humicola
3.5.1.38 Ni2+ 33% inhibition at 1 mM Tilachlidium humicola
3.5.1.38 p-chloromercuribenzoate slight inhibition Tilachlidium humicola

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.38 0.3
-
L-asparagine
-
Tilachlidium humicola
3.5.1.38 0.6
-
L-glutamine
-
Tilachlidium humicola

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.38 extracellular
-
Tilachlidium humicola
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.38 Fe3+ 30% activation at 1 mM Tilachlidium humicola

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.38 L-asparagine + H2O Tilachlidium humicola
-
L-aspartate + NH3
-
?
3.5.1.38 L-glutamine + H2O Tilachlidium humicola lower activity than for L-asparagine L-glutamate + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.38 Tilachlidium humicola
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.38 partial Tilachlidium humicola

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.38 cell culture enzyme formation affected by culture conditions Tilachlidium humicola
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.1.38 17.2
-
-
Tilachlidium humicola

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.38 D-asparagine + H2O
-
Tilachlidium humicola D-aspartate + NH3
-
?
3.5.1.38 D-glutamine + H2O low activity Tilachlidium humicola D-glutamate + NH3
-
?
3.5.1.38 L-asparagine + H2O
-
Tilachlidium humicola L-aspartate + NH3
-
?
3.5.1.38 L-glutamine + H2O lower activity than for L-asparagine Tilachlidium humicola L-glutamate + NH3
-
?

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.5.1.38 37 55
-
Tilachlidium humicola

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.1.38 37
-
stable within 16 h between pH 4-10 Tilachlidium humicola

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.5.1.38 7.2
-
less stable than at pH 5.6 or pH 10 Tilachlidium humicola

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.38 7.2 8.4 D-asparagine mixed type of competitive and non-competitive inhibition Tilachlidium humicola