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Literature summary extracted from

  • Nelson, D.; Rumsey, W.L.; Erecinska, M.
    Glutamine catabolism by heart muscle. Properties of phosphate-activated glutaminase (1992), Biochem. J., 282, 559-564.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.2 ATP enhances activity Rattus norvegicus
3.5.1.2 citrate enhances activity Rattus norvegicus
3.5.1.2 Lactate enhances activity Rattus norvegicus
3.5.1.2 malate enhances activity Rattus norvegicus
3.5.1.2 phosphate activates Rattus norvegicus
3.5.1.2 sulfate activates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.2 glutamate
-
 Rattus norvegicus
3.5.1.2 NEM 1 mM, almost completely blocks activity Rattus norvegicus
3.5.1.2 NH4+ no effect Rattus norvegicus
3.5.1.2 Triton X-100
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.2 4.4
-
 Gln
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.2 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.2 L-Gln + H2O Rattus norvegicus the enzyme produces myocardial Glu L-Glu + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.2 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.2 Gln + H2O
-
 Rattus norvegicus Glu + NH3
-
 ?
3.5.1.2 L-Gln + H2O the enzyme produces myocardial Glu Rattus norvegicus L-Glu + NH3
-
 ?