Literature summary extracted from

Hammock, B.D.; Prestwich, G.D.; Loury, D.N.; Cheung, P.Y.K.; Eng, W.S.; Park, S.K.; Moody, D.E.; Silva, M.H.; Wixtrom, R.N.
Comparison of crude and affinity purified cytosolic epoxide hydrolases from hepatic tissue of control and clofibrate-fed mice (1986), Arch. Biochem. Biophys., 244, 292-309.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.3.2.10	Chalcone oxide	substituted chalcone oxides, potent reversible inhibitors	Mus musculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.3.2.10	4'-azidochalcone oxide	-	Mus musculus
3.3.2.10	4'-phenylchalcone oxide	-	Mus musculus
3.3.2.10	4-azidochalcone oxide	-	Mus musculus
3.3.2.10	4-fluorochalcone oxide	-	Mus musculus
3.3.2.10	4-Phenylchalcone oxide	-	Mus musculus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.3.2.10	cytosol	-	Mus musculus	5829	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.3.2.10	55000	-	gel filtration	Mus musculus
3.3.2.10	59000	-	1 * 59000, monomeric and dimeric enzyme forms retain catalytic activity, SDS-PAGE	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.3.2.10	Mus musculus	-	untreated and clofibrate-treated animals	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.3.2.10	-	Mus musculus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.3.2.10	liver	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.3.2.10	benzopyrene 4,5-oxide + H2O	-	Mus musculus	(-)benzopyrene 4,5-dihydrodiol	-	?
3.3.2.10	cis-stilbene oxide + H2O	-	Mus musculus	?	-	?
3.3.2.10	trans-stilbene oxide + H2O	-	Mus musculus	?	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.3.2.10	monomer	1 * 59000, monomeric and dimeric enzyme forms retain catalytic activity, SDS-PAGE	Mus musculus

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Release 2023.1 (January 2023)