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Literature summary extracted from
- Endogenous role of microsomal epoxide hydrolase. Ontogenesis, induction inhibition, tissue distribution, immunological behaviour and purification of microsomal epoxide hydrolase with 16alpha,17alpha-epoxyandrostene-3-one as substrate (1982), Eur. J. Biochem., 126, 425-431.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.3.2.9 | androstene oxide | inhibits hydration of estroxide and styrene 7,8-oxide | Rattus norvegicus |  |
| 3.3.2.9 | Cyclohexene oxide | inhibits hydration of estroxide, androstene oxide and styrene 7,8-oxide | Rattus norvegicus | |
| 3.3.2.9 | estroxide | inhibits hydration of androstene oxide and styrenen 7,8-oxide | Rattus norvegicus | |
| 3.3.2.9 | sodium cholate | inhibits hydration of estroxide and androstene oxide | Rattus norvegicus | |
| 3.3.2.9 | sodium deoxycholate | inhibits hydration of estroxide and androstene oxide | Rattus norvegicus | |
| 3.3.2.9 | styrene 7,8-oxide | inhibits hydration of estroxide and androstene oxide | Rattus norvegicus | |
| 3.3.2.9 | trans-stilbene oxide | inhibits hydration of estroxide, androstene oxide and styrene 7,8-oxide | Rattus norvegicus | |
| 3.3.2.9 | trichloropropene oxide | inhibits hydration of estroxide, androstene oxide and styrene 7,8-oxide | Rattus norvegicus | |
| 3.3.2.9 | Tween-80 | inhibits hydration of estroxide and androstene oxide | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.3.2.9 | cytosol | no activity detected | Rattus norvegicus | 5829 | - |
| 3.3.2.9 | microsome | - |
Rattus norvegicus | - |
- |
| 3.3.2.9 | mitochondrion | very low activity | Rattus norvegicus | 5739 | - |
| 3.3.2.9 | rough endoplasmic reticulum | - |
Rattus norvegicus | 5791 | - |
| 3.3.2.9 | smooth endoplasmic reticulum | - |
Rattus norvegicus | 5790 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.3.2.9 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.3.2.9 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.3.2.9 | adrenal gland | - |
Rattus norvegicus | - |
| 3.3.2.9 | liver | - |
Rattus norvegicus | - |
| 3.3.2.9 | lung | - |
Rattus norvegicus | - |
| 3.3.2.9 | ovary | - |
Rattus norvegicus | - |
| 3.3.2.9 | testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.9 | androstene oxide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.3.2.9 | benzopyrene 4,5-oxide + H2O | - |
Rattus norvegicus | (-)benzopyrene 4,5-dihydrodiol | - |
? | |
| 3.3.2.9 | estroxide + H2O | 16alpha,17alpha-epoxyestratrienol | Rattus norvegicus | ? | - |
? | |
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Release 2023.1 (January 2023)
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