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Literature summary extracted from

  • Dumas, D.P.; Kajimoto, T.; Liu, K.K.C.; Wong, C.H.
    Azasugars and glycal inhibitors of alpha-L-fucosidase (1992), Bioorg. Med. Chem. Lett., 2, 33-36.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.51 2-(hydroxymethyl)-5-methylpyrrolidine-3,4-diol competitive or uncompetitive inhibition, Ki: 0.004-26 mM, depending on conformation Bos taurus
3.2.1.51 2-methyltetrahydro-2H-pyran-3,4-diol uncompetitive inhibition, Ki: 23 mM Bos taurus
3.2.1.51 2-phenyl-tetrahydro-2H-pyran-3,4-diol uncompetitive inhibition, Ki: 22-83 mM, depending on conformation Bos taurus
3.2.1.51 4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate competitive inhibition, Ki: 0.09 mM Bos taurus
3.2.1.51 5-(hydroxymethyl)pyrrolidine-2,3,4-triol competitive inhibition, Ki: 0.91 mM Bos taurus
3.2.1.51 alpha-L-fucose competitive inhibition, Ki: 0.3 mM Bos taurus
3.2.1.51 D-1-deoxymannojirimycin competitive inhibition, Ki: 0.03 mM Bos taurus
3.2.1.51 D-1-deoxyrhamnojirimycin competitive inhibition, Ki: 0.011 mM Bos taurus
3.2.1.51 D-1-deoxytalonojirimycin competitive inhibition, Ki: 0.053 mM Bos taurus
3.2.1.51 D-fucal uncompetitive inhibition, Ki: 35 mM Bos taurus
3.2.1.51 L-1-deoxyfuconojirimycin competitive inhibition, Ki: 0.00003 mM Bos taurus
3.2.1.51 L-1-deoxymannojirimycin competitive inhibition, Ki: 90 mM Bos taurus
3.2.1.51 L-1-deoxyrhamnojirimycin competitive inhibition, Ki: 1 mM Bos taurus
3.2.1.51 L-fucal competitive inhibition, best inhibitor of glycal compounds tested, Ki: 0.05 mM Bos taurus
3.2.1.51 phenol noncompetitive inhibition, Ki: 112 mM Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.51 Bos taurus
-
bovine
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.51 kidney
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.51 4-nitrophenyl-alpha-L-fucopyranoside + H2O
-
Bos taurus 4-nitrophenol + alpha-L-fucose
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.51 0.00003
-
L-1-deoxyfuconojirimycin competitive inhibition Bos taurus
3.2.1.51 0.004 26 2-(hydroxymethyl)-5-methylpyrrolidine-3,4-diol competitive or uncompetitive inhibition, depending on conformation Bos taurus
3.2.1.51 0.011
-
D-1-deoxyrhamnojirimycin competitive inhibition Bos taurus
3.2.1.51 0.03
-
D-1-deoxymannojirimycin competitive inhibition Bos taurus
3.2.1.51 0.05
-
L-fucal competitive inhibition, best inhibitor of glycal compounds tested Bos taurus
3.2.1.51 0.053
-
D-1-deoxytalonojirimycin competitive inhibition Bos taurus
3.2.1.51 0.09
-
4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate competitive inhibition Bos taurus
3.2.1.51 0.91
-
5-(hydroxymethyl)pyrrolidine-2,3,4-triol competitive inhibition Bos taurus
3.2.1.51 1
-
L-1-deoxyrhamnojirimycin competitive inhibition Bos taurus
3.2.1.51 22 83 2-phenyl-tetrahydro-2H-pyran-3,4-diol uncompetitive inhibition, depending on conformation Bos taurus
3.2.1.51 23
-
2-methyltetrahydro-2H-pyran-3,4-diol uncompetitive inhibition Bos taurus
3.2.1.51 35
-
D-fucal uncompetitive inhibition Bos taurus
3.2.1.51 90
-
L-1-deoxymannojirimycin competitive inhibition Bos taurus
3.2.1.51 112
-
phenol noncompetitive inhibition Bos taurus