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Literature summary extracted from

  • Razzell, W.E.
    Phosphodiesterases (1963), Methods Enzymol., 6, 236-258.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.1 ADP 40% inhibition Sus scrofa
3.1.4.1 AMP 100% inhibition Sus scrofa
3.1.4.1 ATP 20% inhibition Sus scrofa
3.1.4.1 EDTA high concentration Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.1 microsome
-
 Sus scrofa
-
-
3.1.4.1 nucleus
-
 Sus scrofa 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.1 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.1 kidney Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.1 intestine intestinal mucosa Sus scrofa
-
3.1.4.1 kidney
-
 Sus scrofa
-
3.1.4.1 liver
-
 Sus scrofa
-
3.1.4.1 lung
-
 Sus scrofa
-
3.1.4.1 mucosa
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.1 15.5 29
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.1 ADP + H2O
-
 Sus scrofa AMP + phosphate
-
 ?
3.1.4.1 ATP + H2O
-
 Sus scrofa 5'-AMP + diphosphate
-
 ?
3.1.4.1 GDP-mannose + H2O
-
 Sus scrofa ?
-
 ?
3.1.4.1 additional information enzyme does not have a strict base specificity, it does not attack oligonucleotides with a 3'-phosphate terminal Sus scrofa ?
-
 ?
3.1.4.1 additional information no activity with p-nitrophenylthymidine 3'-phosphate Sus scrofa ?
-
 ?
3.1.4.1 oligonucleotides + H2O specific for 3'-5'-direction from the 3'-hydroxyl terminal in a stepwise manner Sus scrofa oligonucleotides(n-1) + 5'-mononucleotides
-
 ?
3.1.4.1 p-nitrophenylthymidine 5'-phosphate + H2O
-
 Sus scrofa 5'-TMP + p-nitrophenol
-
 ?
3.1.4.1 UDP-glucose + H2O
-
 Sus scrofa glucose-1-phosphate + 5'-UMP
-
 ?

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.4.1 6 9.5
-
 Sus scrofa

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.1.4.1 5.1
-
 stable above in cold, but rapidly and apparently irreversibly inactivated at pH 4.5 Sus scrofa