Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Stefanovic, V.; Vlahovic, P.; Ardaillou, R.
    Characterization and control of expression of cell surface alkaline phosphodiesterase I activity in rat mesangial glomerular cells (1995), Renal Physiol. Biochem., 18, 12-20.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.1 dexamethasone increases alkaline phosphodiesterase I in a dose- and time-dependent manner, maximal increase after treatment with 0.001 mM dexamethasone for 5 days, stimulation by dexamethasone is suppressed by cycloheximide and RU 38486 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.1 p-Diazobenzenesulfonic acid DASA: 84% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.1 0.41
-
 p-nitrophenylthymidine 5'-phosphate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.1 cytoplasmic membrane
-
 Rattus norvegicus
-
-
3.1.4.1 extracellular
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.1 additional information Rattus norvegicus phosphodiesterase activity results in the cleavage of nucleotides from nucleic acids and thus may be involved in catabolism of extracellular DNA. Essential function may be to hydrolyze polyribo- and polydeoxyribonucleotides. The enzyme may be important in cell differentiation during carcinogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.1 macrophage
-
 Rattus norvegicus
-
3.1.4.1 mesangial cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.1 DNA + H2O
-
 Rattus norvegicus DNA(n-1) + 2'-deoxynucleoside 5'-phosphate
-
 ?
3.1.4.1 additional information phosphodiesterase activity results in the cleavage of nucleotides from nucleic acids and thus may be involved in catabolism of extracellular DNA. Essential function may be to hydrolyze polyribo- and polydeoxyribonucleotides. The enzyme may be important in cell differentiation during carcinogenesis Rattus norvegicus ?
-
 ?
3.1.4.1 NAD+ + H2O pyrophosphatase activity Rattus norvegicus 5'-AMP + NMN
-
 ?
3.1.4.1 oligonucleotides + H2O
-
 Rattus norvegicus oligonucleotides(n-1) + 5'-mononucleotides
-
 ?
3.1.4.1 p-nitrophenylthymidine 5'-phosphate + H2O
-
 Rattus norvegicus 5'-TMP + p-nitrophenol
-
 ?
3.1.4.1 polynucleotides + H2O specific for 3'-5'-direction from the 3'-hydroxyl terminal in a stepwise manner Rattus norvegicus polynucleotides(n-1) + 5'-mononucleotides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.1 alkaline phosphodiesterase alkaline phosphodiesterase I Rattus norvegicus
3.1.4.1 nucleotide pyrophosphatase/phosphodiesterase I membrane alkaline phosphodiesterase is the same enzyme as nucleotide pyrophosphatase Rattus norvegicus