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Literature summary extracted from
- Biochemical characterization of human PC-1, an enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities (1994), Eur. J. Biochem., 226, 433-443.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.4.1 | cDNA encoding PC-1 | Mus musculus |
| 3.1.4.1 | cDNA encoding PC-1 | Homo sapiens |
| 3.1.4.1 | PC-1, expression in COS cells and in mouse L cells | Mus musculus |
| 3.1.4.1 | PC-1, expression in COS cells and in mouse L cells | Homo sapiens |
| 3.6.1.9 | expression in Cos-7 and mouse Ltk- cells | Mus musculus |
| 3.6.1.9 | expression in Cos-7 and mouse Ltk- cells | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.1 | cytoplasmic membrane | PC-1 | Mus musculus | - |
- |
| 3.1.4.1 | cytoplasmic membrane | PC-1 | Homo sapiens | - |
- |
| 3.1.4.1 | extracellular | PC-1, active site of plasma-membrane-associated PC-1 appears to be located extracellularly | Mus musculus | - |
- |
| 3.1.4.1 | extracellular | PC-1, active site of plasma-membrane-associated PC-1 appears to be located extracellularly | Homo sapiens | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.1 | Ca2+ | PC-1, activation | Mus musculus |  |
| 3.1.4.1 | Ca2+ | PC-1, activation | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.1 | 120000 | - |
2 * 120000, PC-1, homodimer, SDS-PAGE | Mus musculus |
| 3.1.4.1 | 130000 | - |
2 * 130000, PC-1, homodimer, SDS-PAGE | Homo sapiens |
| 3.1.4.1 | 240000 | - |
PC-1, SDS-PAGE without reduction | Mus musculus |
| 3.1.4.1 | 260000 | - |
PC-1, SDS-PAGE without reduction | Homo sapiens |
| 3.6.1.9 | 120000 | - |
2 * 120000, reducing SDS-PAGE | Mus musculus |
| 3.6.1.9 | 130000 | - |
2 * 130000, reducing SDS-PAGE, disulfide-bound | Homo sapiens |
| 3.6.1.9 | 240000 | - |
non-reducing SDS-PAGE | Mus musculus |
| 3.6.1.9 | 260000 | - |
non-reducing SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.1 | additional information | Mus musculus | PC-1, PC-1 may take part in purine uptake for metabolic needs of cells | ? | - |
? | |
| 3.1.4.1 | additional information | Homo sapiens | PC-1, PC-1 may take part in purine uptake for metabolic needs of cells | ? | - |
? | |
| 3.6.1.9 | ADP + H2O | Homo sapiens | - |
AMP + phosphate | - |
? | |
| 3.6.1.9 | ATP + H2O | Mus musculus | - |
AMP + diphosphate | - |
? | |
| 3.6.1.9 | ATP + H2O | Homo sapiens | - |
AMP + diphosphate | - |
? | |
| 3.6.1.9 | UDP-glucose + H2O | Homo sapiens | - |
UMP + D-glucose-1-phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.1 | Homo sapiens | - |
PC-1 | - |
| 3.1.4.1 | Mus musculus | - |
PC-1 | - |
| 3.6.1.9 | Homo sapiens | - |
- |
- |
| 3.6.1.9 | Mus musculus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.1.4.1 | glycoprotein | PC-1, N-linked carbohydrates comprise about 20 kDa | Mus musculus |
| 3.1.4.1 | glycoprotein | PC-1, N-linked carbohydrates comprise about 30 kDa | Homo sapiens |
| 3.1.4.1 | glycoprotein | PC-1, type-II trans-membrane glycoprotein | Mus musculus |
| 3.1.4.1 | glycoprotein | PC-1, type-II trans-membrane glycoprotein | Homo sapiens |
| 3.6.1.9 | glycoprotein | N-linked oligosaccharides, human 120 kDa-precursor form possesses high-mannose oligosaccharides, which disappear in the mature 130 kDa form | Mus musculus |
| 3.6.1.9 | glycoprotein | N-linked oligosaccharides, human 120 kDa-precursor form possesses high-mannose oligosaccharides, which disappear in the mature 130 kDa form | Homo sapiens |
| 3.6.1.9 | phosphoprotein | autophosphorylation | Mus musculus |
| 3.6.1.9 | phosphoprotein | autophosphorylation | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.1 | ADP + H2O | PC-1 | Mus musculus | AMP + phosphate | - |
? | |
| 3.1.4.1 | ADP + H2O | PC-1 | Homo sapiens | AMP + phosphate | - |
? | |
| 3.1.4.1 | ATP + H2O | PC-1 | Mus musculus | 5'-AMP + diphosphate | - |
? | |
| 3.1.4.1 | ATP + H2O | PC-1 | Homo sapiens | 5'-AMP + diphosphate | - |
? | |
| 3.1.4.1 | cyclic 3',5'-mononucleotides + H2O | PC-1 | Mus musculus | mononucleoside 5'-phosphate | - |
? | |
| 3.1.4.1 | cyclic 3',5'-mononucleotides + H2O | PC-1 | Homo sapiens | mononucleoside 5'-phosphate | - |
? | |
| 3.1.4.1 | cyclic 3',5'-mononucleotides + H2O | phosphodiester bonds | Mus musculus | mononucleoside 5'-phosphate | - |
? | |
| 3.1.4.1 | cyclic 3',5'-mononucleotides + H2O | phosphodiester bonds | Homo sapiens | mononucleoside 5'-phosphate | - |
? | |
| 3.1.4.1 | DNA + H2O | PC-1 | Mus musculus | DNA(n-1) + 2'-deoxynucleoside 5'-phosphate | - |
? | |
| 3.1.4.1 | DNA + H2O | PC-1 | Homo sapiens | DNA(n-1) + 2'-deoxynucleoside 5'-phosphate | - |
? | |
| 3.1.4.1 | DNA + H2O | enzyme hydrolyzes single-stranded DNA, no activity with double-stranded DNA | Mus musculus | DNA(n-1) + 2'-deoxynucleoside 5'-phosphate | - |
? | |
| 3.1.4.1 | DNA + H2O | enzyme hydrolyzes single-stranded DNA, no activity with double-stranded DNA | Homo sapiens | DNA(n-1) + 2'-deoxynucleoside 5'-phosphate | - |
? | |
| 3.1.4.1 | additional information | PC-1, PC-1 may take part in purine uptake for metabolic needs of cells | Mus musculus | ? | - |
? | |
| 3.1.4.1 | additional information | PC-1, PC-1 may take part in purine uptake for metabolic needs of cells | Homo sapiens | ? | - |
? | |
| 3.1.4.1 | oligonucleotides + H2O | PC-1 | Mus musculus | oligonucleotides(n-1) + 5'-mononucleotides | - |
? | |
| 3.1.4.1 | oligonucleotides + H2O | PC-1 | Homo sapiens | oligonucleotides(n-1) + 5'-mononucleotides | - |
? | |
| 3.1.4.1 | p-nitrophenyl phenylphosphonate + H2O | - |
Mus musculus | p-nitrophenol + benzenephosphonic acid | - |
? | |
| 3.1.4.1 | p-nitrophenyl phenylphosphonate + H2O | - |
Homo sapiens | p-nitrophenol + benzenephosphonic acid | - |
? | |
| 3.1.4.1 | polynucleotides + H2O | PC-1 | Mus musculus | polynucleotides(n-1) + 5'-mononucleotides | - |
? | |
| 3.1.4.1 | polynucleotides + H2O | PC-1 | Homo sapiens | polynucleotides(n-1) + 5'-mononucleotides | - |
? | |
| 3.1.4.1 | RNA + H2O | PC-1 | Mus musculus | RNA(n-1) + nucleoside 5'-phosphate | - |
? | |
| 3.1.4.1 | RNA + H2O | PC-1 | Homo sapiens | RNA(n-1) + nucleoside 5'-phosphate | - |
? | |
| 3.6.1.9 | ADP + H2O | - |
Homo sapiens | AMP + phosphate | - |
? | |
| 3.6.1.9 | ATP + H2O | - |
Mus musculus | AMP + diphosphate | - |
? | |
| 3.6.1.9 | ATP + H2O | - |
Homo sapiens | AMP + diphosphate | - |
? | |
| 3.6.1.9 | p-nitrophenyl phenylphosphonate + H2O | phosphodiesterase-1 activity | Mus musculus | p-nitrophenol + phenylphosphonate | - |
? | |
| 3.6.1.9 | p-nitrophenyl phenylphosphonate + H2O | phosphodiesterase-1 activity | Homo sapiens | p-nitrophenol + phenylphosphonate | - |
? | |
| 3.6.1.9 | UDP-glucose + H2O | - |
Homo sapiens | UMP + D-glucose-1-phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.4.1 | dimer | 2 * 120000, PC-1, homodimer, SDS-PAGE | Mus musculus |
| 3.1.4.1 | dimer | 2 * 130000, PC-1, homodimer, SDS-PAGE | Homo sapiens |
| 3.6.1.9 | dimer | 2 * 130000, reducing SDS-PAGE, disulfide-bound | Homo sapiens |
| 3.6.1.9 | dimer | 2 * 120000, reducing SDS-PAGE | Mus musculus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.1 | 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I | - |
Mus musculus |
| 3.1.4.1 | 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I | - |
Homo sapiens |
| 3.1.4.1 | 5'NPDE | 5'-nucleotide phosphodiesterase/alkaline phosphodiesterase | Homo sapiens |
| 3.1.4.1 | alkaline phosphodiesterase | alkaline phosphodiesterase I | Homo sapiens |
| 3.1.4.1 | PC-1 | PC-1, plasma-cell differentiation antigen-1, membrane glycoprotein, has 5'-nucleotide phosphodiesterase and nucleotide pyrophosphatase activity | Mus musculus |
| 3.1.4.1 | PC-1 | PC-1, plasma-cell differentiation antigen-1, membrane glycoprotein, has 5'-nucleotide phosphodiesterase and nucleotide pyrophosphatase activity | Homo sapiens |
| 3.6.1.9 | nucleotide pyrophosphatase/phosphodiesterase-I | - |
Mus musculus |
| 3.6.1.9 | nucleotide pyrophosphatase/phosphodiesterase-I | - |
Homo sapiens |
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