EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.283 | iodoacetate | activation of enzyme MGR I, inhibition of enzyme MGR II | Aspergillus niger | |
1.1.1.283 | N-ethylmaleimide | activation of enzyme MGR I, inhibition of enzyme MGR II | Aspergillus niger | |
1.1.1.283 | p-chloromercuribenzoate | activation of enzyme MGR I, inhibition of enzyme MGR II | Aspergillus niger |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.283 | 2-mercaptoethanol | - |
Aspergillus niger | |
1.1.1.283 | Ca2+ | enzymes MGR I (slightly), MGR II | Aspergillus niger | |
1.1.1.283 | Co2+ | activates enzyme MGR I, slightly inhibits enzyme MGR II | Aspergillus niger | |
1.1.1.283 | Cu2+ | enzymes MGR I and MGR II | Aspergillus niger | |
1.1.1.283 | dithiothreitol | - |
Aspergillus niger | |
1.1.1.283 | EDTA | - |
Aspergillus niger | |
1.1.1.283 | Glyoxal | in absence of NADPH | Aspergillus niger | |
1.1.1.283 | iodoacetate | activation of enzyme MGR I, inhibition of enzyme MGR II | Aspergillus niger | |
1.1.1.283 | methylglyoxal | in absence of NADPH | Aspergillus niger | |
1.1.1.283 | Mg2+ | enzymes MGR I and MGR II | Aspergillus niger | |
1.1.1.283 | Mn2+ | enzymes MGR I, MGR II | Aspergillus niger | |
1.1.1.283 | N-ethylmaleimide | activation of enzyme MGR I, inhibition of enzyme MGR II | Aspergillus niger | |
1.1.1.283 | NADP+ | - |
Aspergillus niger | |
1.1.1.283 | Ni2+ | enzyme MGR I | Aspergillus niger | |
1.1.1.283 | p-chloromercuribenzoate | activation of enzyme MGR I, inhibition of enzyme MGR II | Aspergillus niger | |
1.1.1.283 | Phenylglyoxal | in absence of NADPH | Aspergillus niger | |
1.1.1.283 | Zn2+ | enzyme MGR I | Aspergillus niger |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.283 | 0.0068 | - |
NADPH | enzyme MGR II | Aspergillus niger | |
1.1.1.283 | 0.054 | - |
NADPH | enzyme MGR I | Aspergillus niger | |
1.1.1.283 | 0.7 | - |
methylglyoxal | - |
Aspergillus niger | |
1.1.1.283 | 1.43 | - |
methylglyoxal | enzyme MGR I | Aspergillus niger | |
1.1.1.283 | 4.35 | - |
Phenylglyoxal | enzyme MGR II | Aspergillus niger | |
1.1.1.283 | 10 | - |
Glyoxal | enzyme MGR II | Aspergillus niger | |
1.1.1.283 | 15.4 | - |
methylglyoxal | enzyme MGR I | Aspergillus niger |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.283 | Co2+ | activates enzyme MGR I, slightly inhibits enzyme MGR II | Aspergillus niger |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.1.1.283 | 36000 | - |
1 * 36000, enzyme MGR I, 1 * 38000, enzyme MGR II, similar enzyme with NADPH-requirement for methylglyoxal reduction, that is inactive with NAD+, NADH and NADP+, SDS-PAGE | Aspergillus niger |
1.1.1.283 | 37000 | - |
enzyme MGR I, similar enzyme with NADPH-requirement for methylglyoxal reduction, that is inactive with NAD+, NADH and NADP+, gel filtration | Aspergillus niger |
1.1.1.283 | 38000 | - |
enzyme MGR II, similar enzyme with NADPH-requirement for methylglyoxal reduction, that is inactive with NAD+, NADH and NADP+, gel filtration | Aspergillus niger |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.283 | methylglyoxal + NADPH | Aspergillus niger | similar enzyme with NADPH requirement | lactaldehyde + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.283 | Aspergillus niger | - |
2 methylglyoxylate reductases: MGR I and MGR II, similar enzyme with NADPH-requirement for methylglyoxal reduction, that is inactive with NAD+, NADH and NADP+ | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.283 | two methylglyoxylate reductases: MGR I and MGR II, similar enzyme with NADPH-requirement for methylglyoxal reduction, that is inactive with NAD+, NADH and NADP+ | Aspergillus niger |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.1.1.283 | (S)-lactaldehyde + NADP+ = 2-oxopropanal + NADPH + H+ | similar enzyme with NADPH-requirement for methylglyoxal reduction, that is inactive with NAD+, NADH and NADP+ | Aspergillus niger |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.283 | 0.83 | - |
enzyme MGR I | Aspergillus niger |
1.1.1.283 | 7.77 | - |
enzyme MGR II | Aspergillus niger |
EC Number | Storage Stability | Organism |
---|---|---|
1.1.1.283 | 4°C | Aspergillus niger |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.283 | acetaldehyde + NADPH + H+ | enzyme MGR II | Aspergillus niger | ethanol + NADP+ | - |
? | |
1.1.1.283 | glyoxal + NADPH | enzymes MGR I and MGR II | Aspergillus niger | glycolaldehyde + NADP+ | - |
? | |
1.1.1.283 | methylglyoxal + NADPH | similar enzyme with NADPH requirement | Aspergillus niger | lactaldehyde + NADP+ | - |
? | |
1.1.1.283 | additional information | enzyme MGR I: specific for 2-oxoaldehydes (glyoxal phenylglyoxal), enzyme MGR II: active towards 2-oxoaldehydes (glyoxal, methylglyoxal, phenylglyoxal), 4,5-dioxovalerate and some aldehydes (propionaldehyde and acetaldehyde) | Aspergillus niger | ? | - |
? | |
1.1.1.283 | phenylglyoxal + NADPH | enzymes MGR I and MGR II | Aspergillus niger | hydroxyphenylacetaldehyde + NADP+ | - |
? | |
1.1.1.283 | propionaldehyde + NADPH | enzyme MGR II | Aspergillus niger | propanol + NADP+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.1.1.283 | monomer | 1 * 36000, enzyme MGR I, 1 * 38000, enzyme MGR II, similar enzyme with NADPH-requirement for methylglyoxal reduction, that is inactive with NAD+, NADH and NADP+, SDS-PAGE | Aspergillus niger |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.283 | 6.5 | - |
enzyme MGR I | Aspergillus niger |
1.1.1.283 | 9 | - |
enzyme MGR II | Aspergillus niger |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.283 | NADPH | NADPH required | Aspergillus niger |