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Literature summary extracted from

  • Mitz, M.A.; Heinrikson, R.L.
    Omega-hydroxy fatty acid dehydrogenase (1961), Biochim. Biophys. Acta, 46, 45-50.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.66 0.066
-
NAD+
-
Sus scrofa
1.1.1.66 0.08
-
11-Hydroxyundecanoate
-
Sus scrofa
1.1.1.66 0.125
-
10-Hydroxydecanoate
-
Sus scrofa
1.1.1.66 40
-
9-Hydroxynonanoate
-
Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.66 cytoplasm
-
Rattus norvegicus 5737
-
1.1.1.66 cytoplasm
-
Sus scrofa 5737
-
1.1.1.66 cytoplasm
-
Oryctolagus cuniculus 5737
-
1.1.1.66 cytoplasm
-
Ovis aries 5737
-
1.1.1.66 cytoplasm
-
Equus caballus 5737
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.66 Equus caballus
-
-
-
1.1.1.66 Oryctolagus cuniculus
-
-
-
1.1.1.66 Ovis aries
-
-
-
1.1.1.66 Rattus norvegicus
-
-
-
1.1.1.66 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.66
-
Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.66 heart
-
Sus scrofa
-
1.1.1.66 kidney
-
Sus scrofa
-
1.1.1.66 liver
-
Rattus norvegicus
-
1.1.1.66 liver
-
Sus scrofa
-
1.1.1.66 liver
-
Oryctolagus cuniculus
-
1.1.1.66 liver
-
Ovis aries
-
1.1.1.66 liver
-
Equus caballus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.66 additional information
-
223, units defined as change in optical density at 340 nm of 0.001/min Sus scrofa

Storage Stability

EC Number Storage Stability Organism
1.1.1.66 4°C, crude extract stable for a week Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.66 10-hydroxydecanoate + NAD+
-
Rattus norvegicus 10-oxodecanoate + NADH
-
?
1.1.1.66 10-hydroxydecanoate + NAD+
-
Oryctolagus cuniculus 10-oxodecanoate + NADH
-
?
1.1.1.66 10-hydroxydecanoate + NAD+
-
Ovis aries 10-oxodecanoate + NADH
-
?
1.1.1.66 10-hydroxydecanoate + NAD+
-
Equus caballus 10-oxodecanoate + NADH
-
?
1.1.1.66 10-hydroxydecanoate + NAD+ best substrate Sus scrofa 10-oxodecanoate + NADH
-
r
1.1.1.66 11-hydroxyundecanoate + NAD+
-
Rattus norvegicus 11-oxoundecanoate + NADH
-
?
1.1.1.66 11-hydroxyundecanoate + NAD+
-
Oryctolagus cuniculus 11-oxoundecanoate + NADH
-
?
1.1.1.66 11-hydroxyundecanoate + NAD+
-
Ovis aries 11-oxoundecanoate + NADH
-
?
1.1.1.66 11-hydroxyundecanoate + NAD+
-
Equus caballus 11-oxoundecanoate + NADH
-
?
1.1.1.66 11-hydroxyundecanoate + NAD+ oxidation at 89% the rate of 10-hydroxydecanoic acid Sus scrofa 11-oxoundecanoate + NADH
-
?
1.1.1.66 9-hydroxynonanoate + NAD+
-
Rattus norvegicus 9-oxononanoate + NADH
-
?
1.1.1.66 9-hydroxynonanoate + NAD+
-
Oryctolagus cuniculus 9-oxononanoate + NADH
-
?
1.1.1.66 9-hydroxynonanoate + NAD+
-
Ovis aries 9-oxononanoate + NADH
-
?
1.1.1.66 9-hydroxynonanoate + NAD+
-
Equus caballus 9-oxononanoate + NADH
-
?
1.1.1.66 9-hydroxynonanoate + NAD+ oxidation at 51% the rate of 10-hydroxydecanoic acid Sus scrofa 9-oxononanoate + NADH
-
?
1.1.1.66 additional information C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized Rattus norvegicus ?
-
?
1.1.1.66 additional information C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized Sus scrofa ?
-
?
1.1.1.66 additional information C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized Oryctolagus cuniculus ?
-
?
1.1.1.66 additional information C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized Ovis aries ?
-
?
1.1.1.66 additional information C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized Equus caballus ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.66 37
-
assay at Rattus norvegicus
1.1.1.66 37
-
assay at Sus scrofa
1.1.1.66 37
-
assay at Oryctolagus cuniculus
1.1.1.66 37
-
assay at Ovis aries
1.1.1.66 37
-
assay at Equus caballus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.66 10
-
-
Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.66 9 11 about half-maximal activity at pH 9.0 and 11.0 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.66 NAD+ cannot be replaced by NADP+ Rattus norvegicus
1.1.1.66 NAD+ cannot be replaced by NADP+ Sus scrofa
1.1.1.66 NAD+ cannot be replaced by NADP+ Oryctolagus cuniculus
1.1.1.66 NAD+ cannot be replaced by NADP+ Ovis aries
1.1.1.66 NAD+ cannot be replaced by NADP+ Equus caballus