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Literature summary extracted from
- Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis (1994), J. Biol. Chem., 269, 12710-12714.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.1.1 | 2 | - |
D-Ala | - |
Tolypocladium inflatum |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.1 | 37000 | - |
3 or 4 * 37000, SDS-PAGE | Tolypocladium inflatum |
| 5.1.1.1 | 120000 | 150000 | gel filtration | Tolypocladium inflatum |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.1.1 | additional information | Tolypocladium inflatum | key enzyme in cyclosporin A biosynthesis | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.1.1.1 | Tolypocladium inflatum | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.1.1.1 | - |
Tolypocladium inflatum |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.1 | 143 | - |
- |
Tolypocladium inflatum |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.1.1 | L-Ala | - |
Tolypocladium inflatum | D-Ala | - |
? | |
| 5.1.1.1 | additional information | key enzyme in cyclosporin A biosynthesis | Tolypocladium inflatum | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.1.1.1 | ? | 3 or 4 * 37000, SDS-PAGE | Tolypocladium inflatum |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.1 | 42 | - |
L-Ala | Tolypocladium inflatum |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.1.1.1 | 8.8 | - |
L-Ala | Tolypocladium inflatum |
| 5.1.1.1 | 9.5 | - |
D-Ala | Tolypocladium inflatum |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.1 | pyridoxal 5'-phosphate | required as coenzyme | Tolypocladium inflatum | |
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