Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Elder, R.H.; Montecucco, A.; Carrocchi, G.; Rossignol, J.M.
    Rat liver DNA ligase. Catalytic properties of a novel form of DNA ligase (1992), Eur. J. Biochem., 203, 53-58.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.1 dATP
-
Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.5.1.1 100000
-
novel enzyme form different from DNA ligase I Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Rattus norvegicus
-
a novel enzyme form different from DNA ligase I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.1 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m novel form of enzyme different from DNA ligase I: has a unique binding site, which has an absolute requirement for single-strand breaks, unable to join blunt-ended DNA, even in the presence of polyethylene glycol concentrations which stimulate such joining by DNA ligase I and T4 DNA ligase, the enzyme lacks the AMP-dependent nicking/closing reaction Rattus norvegicus AMP + diphosphate + (deoxyribonucleotide)n+m
-
?