Literature summary extracted from

Yang, S.W.; Huang, P.; Plunkett, W.; Becker, F.F.; Chan, J.Y.
Dual mode of inhibition of purified DNA ligase I from human cells by 9-beta-D-arabinofuranosyl-2-fluoroadenine triphosphate (1992), J. Biol. Chem., 267, 2345-2349.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.5.1.1	9-beta-D-Arabinofuranosyl-2-fluoroadenine triphosphate	0.08 mM, 90% inhibition	Homo sapiens
6.5.1.1	Protein inhibitor	specific inhibitor for DNA ligase I , this protein inhibitor may play a specific role in regulating DNA ligation during replication, repair, or recombination	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.5.1.1	Homo sapiens	-	DNA ligase I	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.5.1.1	ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	-	Homo sapiens	AMP + diphosphate + (deoxyribonucleotide)n+m	-	?

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Release 2023.1 (January 2023)