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Literature summary extracted from

  • Robin, P.; Lindahl, T.
    DNA ligase IV from HeLa cell nuclei (1996), J. Biol. Chem., 271, 24257-24261.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.1 (7R,9R)-idarubicin
-
 Tequatrovirus T4
6.5.1.1 4',6-Diamidino-2-phenylindole
-
 Tequatrovirus T4
6.5.1.1 doxorubicin
-
 Tequatrovirus T4
6.5.1.1 Ethidium bromide
-
 Homo sapiens
6.5.1.1 Ethidium bromide
-
 Tequatrovirus T4

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.5.1.1 nucleus
-
 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
-
 DNA ligase IV
-
6.5.1.1 Tequatrovirus T4
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.1 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Tequatrovirus T4 AMP + diphosphate + (deoxyribonucleotide)n+m
-
 ?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m joins single-strand breaks in a double stranded polydeoxynucleotide in an ATP-dependent reaction, can join the hybrid substrates oligo(dT)*poly(rA) and oligo(rA)*poly(dT) Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
 ?