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Literature summary extracted from

  • Mukhopadhyay, B.; Stoddard, S.F.; Wolfe, R.S.
    Purification, regulation, and molecular and biochemical characterization of pyruvate carboxylase from Methanobacterium thermoautotrophicum (1998), J. Biol. Chem., 273, 5155-5166.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.4.1.1 acetyl-CoA not required Methanothermobacter thermautotrophicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.4.1.1
-
Methanothermobacter thermautotrophicus

General Stability

EC Number General Stability Organism
6.4.1.1 Mg2+ stabilizes Methanothermobacter thermautotrophicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.1 2-oxoglutarate
-
Methanothermobacter thermautotrophicus
6.4.1.1 ADP weak Methanothermobacter thermautotrophicus
6.4.1.1 ATP at high concentrations Methanothermobacter thermautotrophicus
6.4.1.1 Co2+ in presence of Mg2+ Methanothermobacter thermautotrophicus
6.4.1.1 ITP weak Methanothermobacter thermautotrophicus
6.4.1.1 L-Asp no inhibition Methanothermobacter thermautotrophicus
6.4.1.1 Mn2+ presence of Mg2+ Methanothermobacter thermautotrophicus
6.4.1.1 Zn2+ in presence of Mg2+ Methanothermobacter thermautotrophicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.4.1.1 Co2+ divalent metal required, Mg2+, Mn2+ or Co2+ Methanothermobacter thermautotrophicus
6.4.1.1 Mg2+ divalent metal required, Mg2+, and with lower efficiency Mn2+ or Co2+ Methanothermobacter thermautotrophicus
6.4.1.1 Mn2+ divalent metal required, Mg2+, Mn2+ or Co2+ Methanothermobacter thermautotrophicus

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.1 Methanothermobacter thermautotrophicus
-
-
-
6.4.1.1 Methanothermobacter thermautotrophicus DELTAH
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.4.1.1
-
Methanothermobacter thermautotrophicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.1 ATP + pyruvate + HCO3-
-
Methanothermobacter thermautotrophicus ADP + phosphate + oxaloacetate
-
?
6.4.1.1 ATP + pyruvate + HCO3-
-
Methanothermobacter thermautotrophicus DELTAH ADP + phosphate + oxaloacetate
-
?