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Literature summary extracted from

  • Guy, H.I.; Bouvier, A.; Evans, D.R.
    The smallest carbamoyl-phosphate synthetase. A single catalytic subdomain catalyzes all three partial reactions (1997), J. Biol. Chem., 14; 272, 29255-29262.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.5.5
-
 Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
6.3.5.5 additional information smaller recombinant proteins in which the subdomains A1, A2, A3, B1, B2, or B3 of the synthetase subunit are deleted, show that subdomains A1 and B1 are attenuation domains which suppress the intrinsically high activity and are required for the physical association with the glutaminase subunit Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.5.5 40000
-
 1 * 40000, glutaminase subunit, + 1 * 120000, synthase subunit. The synthase subunit consists of two homologous domains, CPS.A and CPS.B, which catalyze the two different ATP-dependent partial reactions involved in carbamoyl-phosphate synthesis Escherichia coli
6.3.5.5 120000
-
 1 * 40000, glutaminase subunit, + 1 * 120000, synthase subunit. The synthase subunit consists of two homologous domains, CPS.A and CPS.B, which catalyze the two different ATP-dependent partial reactions involved in carbamoyl-phosphate synthesis Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.5 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.5.5 dimer 1 * 40000, glutaminase subunit, + 1 * 120000, synthase subunit. The synthase subunit consists of two homologous domains, CPS.A and CPS.B, which catalyze the two different ATP-dependent partial reactions involved in carbamoyl-phosphate synthesis Escherichia coli