Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ingraham, J.L.; Abdelal, A.T.H.
    Carbamoyl-phosphate synthetase (glutamine): Salmonella (1978), Methods Enzymol., 51, 29-35.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.5.5 5-phospho-alpha-D-ribosyl 1-diphosphate stimulates Salmonella enterica subsp. enterica serovar Typhimurium
6.3.5.5 Orn activates Salmonella enterica subsp. enterica serovar Typhimurium

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.5 UMP
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.5.5 45000
-
 1 * 45000, beta, + 1 * 110000, alpha Salmonella enterica subsp. enterica serovar Typhimurium
6.3.5.5 110000
-
 1 * 45000, beta, + 1 * 110000, alpha Salmonella enterica subsp. enterica serovar Typhimurium
6.3.5.5 150000
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.5.5 ATP + L-Gln + HCO3- Salmonella enterica subsp. enterica serovar Typhimurium catalyzes the synthesis of all carbamoyl phosphate which serves two metabolic functions: it is an intermediate in synthesis of arginine and in the synthesis of pyrimidines ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.5 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.5.5 liver
-
 Salmonella enterica subsp. enterica serovar Typhimurium
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.5.5 4.166
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
6.3.5.5 ATP + L-Gln + HCO3- catalyzes the synthesis of all carbamoyl phosphate which serves two metabolic functions: it is an intermediate in synthesis of arginine and in the synthesis of pyrimidines Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.5.5 dimer 1 * 45000, beta, + 1 * 110000, alpha Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.5.5 7.6 8.5 Gln-dependent activity Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.5.5 IMP stimulates Salmonella enterica subsp. enterica serovar Typhimurium