Literature summary extracted from

Aoki, T.; Oya, H.
Inactivation of Crithidia fasciculata carbamoyl phosphate synthetase II by the antitumor drug acivicin (1987), Mol. Biochem. Parasitol., 23, 173-181.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
6.3.5.5	acivicin	selective time-dependent inhibition of L-Gln-dependent activity, L-Gln protects the enzyme from inactivation. Stimulation of NH4+-dependent activity	Crithidia fasciculata

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.3.5.5	acivicin	selective time-dependent inhibition of L-Gln-dependent activity, L-Gln protects the enzyme from inactivation. Stimulation of NH4+-dependent activity	Crithidia fasciculata

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6.3.5.5	ATP + L-Gln + HCO3-	Crithidia fasciculata	catalyzes the first step of de novo pyrimidine biosynthesis	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.5.5	Crithidia fasciculata	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.5.5	2 ATP + L-Gln + HCO3-	-	Crithidia fasciculata	2 ADP + phosphate + L-Glu + carbamoyl phosphate	-	?
6.3.5.5	ATP + L-Gln + HCO3-	catalyzes the first step of de novo pyrimidine biosynthesis	Crithidia fasciculata	?	-	?

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Release 2023.1 (January 2023)