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Literature summary extracted from

  • Christopherson, R.I.; Williams, N.K.; Schoettle, S.L.; Szabados, E.; Hambley, T.W.; Manthey, M.K.
    Inhibitors of dihydroorotase, amidophosphoribosyltransferase and IMP cyclohydrolase as potential drugs (1995), Biochem. Soc. Trans., 23, 888-893.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.3 2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylate
-
Cricetinae
3.5.2.3 L-6-thiodihydroorotate
-
Cricetinae
3.5.4.10 2-fluoroadenine arabinoside 5'-monophosphate strong competitive inhibitor, derivative of anti-cancer drug Homo sapiens
3.5.4.10 2-mercaptoinosine 5'-monophosphate most potent competitive inhibitor, precursor of GMP in the purine pathway Homo sapiens
3.5.4.10 6-mercaptopurine riboside 5'-monophosphate strong competitive inhibitor, derivative of anti-cancer drug Homo sapiens
3.5.4.10 adenosine N1-oxide 5'-monophosphate strong competitive inhibitor Homo sapiens
3.5.4.10 N6-(carboxymethyl)adenosine 5'-monophosphate strong competitive inhibitor Homo sapiens
3.5.4.10 xanthosine 5'-monophosphate strong competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.10 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide Homo sapiens de novo purine synthesis step 10 ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.3 Cricetinae
-
-
-
3.5.4.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.10 CEM cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.10 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide de novo purine synthesis step 10 Homo sapiens ?
-
?