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Literature summary extracted from

  • Lieberman, I.; Kornberg, A.
    Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. III. ureidosuccinase (1955), J. Biol. Chem., 212, 909-920.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.7 cysteine
-
Faecalicatena orotica
3.5.1.7 glutathione effect less than half that of cysteine Faecalicatena orotica
3.5.1.7 sulfhydryl compound
-
Faecalicatena orotica

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.7 Sodium thioglycolate
-
Faecalicatena orotica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.7 Cu2+
-
Faecalicatena orotica
3.5.1.7 Fe2+
-
Faecalicatena orotica
3.5.1.7 Mn2+ absolute requirement Faecalicatena orotica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.7 L-ureidosuccinic acid + H2O Faecalicatena orotica only the L-isomer is attacked, the D form is completely inactive ?
-
?
3.5.1.7 additional information Faecalicatena orotica L-carboxymethylhydantoin is no substrate ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.7 Faecalicatena orotica
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.7
-
Faecalicatena orotica

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.1.7 7.4
-
-
Faecalicatena orotica

Storage Stability

EC Number Storage Stability Organism
3.5.1.7 0°C stable for at least 10 days if kept in vacuo, loses activity rapidly when exposed to air either at 0°C or -16°C Faecalicatena orotica

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.7 carbamoylglutamate + H2O small amount of activity found Faecalicatena orotica ?
-
?
3.5.1.7 L-carboxymethylhydantoin + H2O inert substrate Faecalicatena orotica CO2 + ?
-
?
3.5.1.7 L-ureidosuccinic acid + H2O only the L-isomer was attacked, the D form is completely inactive Faecalicatena orotica L-aspartic acid + CO2 + NH3
-
?
3.5.1.7 L-ureidosuccinic acid + H2O only the L-isomer is attacked, the D form is completely inactive Faecalicatena orotica ?
-
?
3.5.1.7 additional information L-carboxymethylhydantoin is no substrate Faecalicatena orotica ?
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.7 7.8 8.5
-
Faecalicatena orotica

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.1.7 5.1 9.6
-
Faecalicatena orotica