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Literature summary extracted from

  • Evangelatos, S.A.; Kakabakos, S.E.; Evangelatos, G.P.; Ithakissios, D.S.
    Determination of serum biotinidase activity with biotinyl derivatives of iodotyramines as substrates (1993), J. Pharm. Sci., 82, 1228-1231.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.12 medicine plasma biotinidase activity assay for diagnosis and screen newborn infants for biotinidase deficiency, treatment of inborn metabolism errors with large doses of biotin Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.12 0.0158
-
 biotinyl-monoiodotyramine
-
 Homo sapiens
3.5.1.12 0.0259
-
 biotinyl-di-iodotyramine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.12 biotin amide + H2O Homo sapiens
-
 ?
-
 ?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.12 Homo sapiens
-
 human
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.12 blood serum, plasma, leukocytes Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.12 biotin amide + H2O
-
 Homo sapiens ?
-
 ?
3.5.1.12 biotinyl-di-iodotyramine + H2O radioactive assay for early diagnosis of biotinidase defiency in serum Homo sapiens biotin + di-iodotyramine
-
 ?
3.5.1.12 biotinyl-monoiodotyramine + H2O radioactive assay for early diagnosis of biotinidase defiency in serum Homo sapiens biotin + monoiodotyramine
-
 ?
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
 Homo sapiens biotin + L-lysine
-
 ir
3.5.1.12 epsilon-N-biotinyl-L-lysine + H2O
-
 Homo sapiens ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.12 6 6.8
-
 Homo sapiens