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Literature summary extracted from

  • Bailly, V.; Sente, B.; Verly, W.G.
    Bacteriophage-T4 and Micrococcus luteus UV endonucleases are not endonucleases but beta-elimination and sometimes betadelta-elimination catalysts (1989), Biochem. J., 259, 751-759.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.99.18 DNA Micrococcus luteus
-
 fragments of DNA
-
 ?
4.2.99.18 DNA Tequatrovirus T4
-
 fragments of DNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.17 Micrococcus luteus
-
-
-
3.2.2.17 Tequatrovirus T4
-
-
-
4.2.99.18 Micrococcus luteus
-
-
-
4.2.99.18 Tequatrovirus T4
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.17 DNA + H2O
-
 Micrococcus luteus thymine + ?
-
 ?
3.2.2.17 DNA + H2O beta-elimination reaction results in an alpha,beta-unsaturated aldehyde Tequatrovirus T4 thymine + ?
-
 ?
3.2.2.17 additional information 3'nicking is not result of the hydrolysis of the phospho ester bond, but rather result of a beta-elimination reaction, the sequence of the 138 amino acid residues of T4 UV endonuclease is known, active sites for DNA glycosylase and the nicking activity seem to be independent, since endonuclease is a phosphoric diester hydrolase classified as EC 3.1.4.-T4 UV endonuclease and Micrococcus luteus endonuclease are not endonucleases Micrococcus luteus ?
-
 ?
3.2.2.17 additional information 3'nicking is not result of the hydrolysis of the phospho ester bond, but rather result of a beta-elimination reaction, the sequence of the 138 amino acid residues of T4 UV endonuclease is known, active sites for DNA glycosylase and the nicking activity seem to be independent, since endonuclease is a phosphoric diester hydrolase classified as EC 3.1.4.-T4 UV endonuclease and Micrococcus luteus endonuclease are not endonucleases Tequatrovirus T4 ?
-
 ?
4.2.99.18 DNA
-
 Micrococcus luteus fragments of DNA
-
 ?
4.2.99.18 DNA
-
 Tequatrovirus T4 fragments of DNA
-
 ?
4.2.99.18 DNA phage-T4 and Micrococcus luteus enzyme nick the C(3')-O-P-bond 3' to the apurinic/apyrimidinic sites in DNA, the phage enzyme can also subsequently nick the C(5')-O-P bond 5' to the apurinic/apyrimidinic site Micrococcus luteus fragments of DNA
-
 ?
4.2.99.18 DNA phage-T4 and Micrococcus luteus enzyme nick the C(3')-O-P-bond 3' to the apurinic/apyrimidinic sites in DNA, the phage enzyme can also subsequently nick the C(5')-O-P bond 5' to the apurinic/apyrimidinic site Tequatrovirus T4 fragments of DNA
-
 ?