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Literature summary extracted from

  • Foster, J.W.
    Pyridine nucleotide cycle of Salmonella typhimurium: in vitro demonstration of nicotinamide adenine dinucleotide glycohydrolase, nicotinamide mononucleotide glycohydrolase, and nicotinamide adenine dinucleotide pyrophosphatase activities (1981), J. Bacteriol., 145, 1002-1009.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.14 adenosine addition of 1.4 mM, inhibition 54.7% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 ADP-ribose addition of 1-1.4 mM, inhibition 74.4% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 AMP addition of 1.4 mM AMP, inhibition 92.5% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 D-ribose-5-phosphate addition of 1.4 mM, inhibition 42.3% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 desamido-NAD+ addition of 1 mM, inhibition 66.6% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 GMP addition of 1.4 mM GMP, inhibition 89.4% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 guanosine addition of 1.4 mM, inhibition 44.6% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 NAD+ greatly inhibited by intracellular levels of NAD+ and reduced NADH, addition of 1 mM NAD+, inhibition 73.2% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 NADH addition of 1 mM, inhibition 68.6% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 NADP+ addition of 1 mM, inhibition 24% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 nicotinamide hypoxanthine dinucleotide addition of 1 mM nicotinamide hypoxanthine dinucleotide, inhibition 61.4% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 pyridoxal 5'-phosphate addition of 1.4 mM, inhibition 8.8% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 pyridoxal HCl addition of 1.4 mM, inhibition 5.2% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 thio-NAD+ addition of 1 mM, inhibition 63.2% Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.2.14 67000
-
 gel filtration Salmonella enterica subsp. enterica serovar Typhimurium
3.5.1.42 43000
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.22 120000
-
 gel filtration, Sephadex G-150 Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.14 nicotinamide mononucleotide + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
 ?
-
 ?
3.5.1.42 beta-nicotinamide D-ribonucleotide + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
 beta-nicotinate D-ribonucleotide + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.14 Salmonella enterica subsp. enterica serovar Typhimurium
-
 LT-2
-
3.5.1.42 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
3.6.1.22 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.22
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.42 cell culture
-
 Salmonella enterica subsp. enterica serovar Typhimurium
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.2.14 0.032
-
 addition of 1.4 mM GTP, inhibition 93.1% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.034
-
 addition of 1.4 mM AMP, inhibition 92.5% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.049
-
 addition of 1.4 mM GMP, inhibition 89.4% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.117
-
 addition of 1.4 mM ADP-ribose, inhibition 74.4% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.122
-
 addition of 1 mM ADP-ribose, inhibition 74.4% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.128
-
 addition of 1 mM NAD+, inhibition 73.2% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.15
-
 addition of 1 mM NADH, inhibition 68.6% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.16
-
 addition of 1 mM desamido-NAD+, inhibition 66.6% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.176
-
 addition of 1 mM thio-NAD+, inhibition 63.2% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.186
-
 addition of 1 mM NHD, inhibition 61.4% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.208
-
 addition of 1.4 mM adenosine, inhibition 54.7% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.254
-
 addition of 1.4 mM guanosine, inhibition 44.6% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.264
-
 addition of 1.4 mM D-ribose-5-phosphate, inhibition 42.3% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.363
-
 addition of 1 mM NADP+, inhibition 24% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.418
-
 addition of 1.4 mM pyridoxal 5'-phosphate, inhibition 8.8% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.434
-
 addition of 1.4 mM pyridoxal HCl, inhibition 5.2% Salmonella enterica subsp. enterica serovar Typhimurium
3.2.2.14 0.478
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.14 nicotinamide mononucleotide + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
3.5.1.42 beta-nicotinamide D-ribonucleotide + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium beta-nicotinate D-ribonucleotide + NH3
-
 ?
3.6.1.22 NAD+ + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium NMN + AMP
-
 ir

Synonyms

EC Number Synonyms Comment Organism
3.6.1.22 nicotinamide adenine dinucleotide pyrophosphatase
-
-

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.2.14 8
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium