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Literature summary extracted from
- Activation of human brain galactosylceramidase by phosphatidylserine (1979), Biochim. Biophys. Acta, 575, 410-420.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.46 | phosphatidylserine | in absence of sodium taurocholate | Homo sapiens |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.2.1.46 | 0.1 | - |
galactosylceramide | taurocholate activated | Homo sapiens | |
| 3.2.1.46 | 0.2 | - |
galactosylceramide | phosphatidylserine activated | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.46 | D-galactosyl-N-acylsphingosine + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.1.46 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.2.1.46 | partially | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.2.1.46 | brain | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.46 | D-galactosyl-N-acylsphingosine + H2O | - |
Homo sapiens | D-galactose + N-acylsphingosine | - |
? | |
| 3.2.1.46 | D-galactosyl-N-acylsphingosine + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.2.1.46 | galactocerebroside + H2O | - |
Homo sapiens | D-galactose + N-acylceramide | - |
? | |
| 3.2.1.46 | galactosylceramide + H2O | - |
Homo sapiens | D-galactose + N-acylceramide | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.2.1.46 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.2.1.46 | 4.2 | - |
taurocholate activated | Homo sapiens |
| 3.2.1.46 | 4.7 | - |
phosphatidylserine activated | Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.2.1.46 | 3.5 | 6 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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