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Literature summary extracted from
- Purification and characterization of human serum hyaluronidase (1993), Arch. Biochem. Biophys., 305, 434-441.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.35 | bovine serum albumin | - |
Homo sapiens | |
| 3.2.1.35 | NaCl | optimum activity between 0.05-0.1 M | Homo sapiens |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.35 | chondroitin O-sulfate | inhibition between 50-500 ng/ml | Homo sapiens | |
| 3.2.1.35 | dermatan O-sulfate | 10% inhibition at 50 ng/ml | Homo sapiens | |
| 3.2.1.35 | heparan sulfate | 43% inhibition at 500 ng/ml | Homo sapiens | |
| 3.2.1.35 | heparin | 73% inhibition at 500 ng/ml | Homo sapiens | |
| 3.2.1.35 | Hg2+ | moderate inhibition at 20 mM | Homo sapiens | |
| 3.2.1.35 | NaCl | sharp decrease of activity above 0.15 M | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.2.1.35 | extracellular | - |
Homo sapiens | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.35 | Ca2+ | 1.8fold increasing activity at 5 mM | Homo sapiens | |
| 3.2.1.35 | Mg2+ | 1.8fold increasing activity at 5 mM | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.35 | hyaluronic acid + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.1.35 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.2.1.35 | to homogeneity, chromatography steps | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.2.1.35 | serum | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.2.1.35 | additional information | - |
activity measured as turbidicity reducing units | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.35 | hyaluronic acid + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.2.1.35 | hyaluronic acid + H2O | - |
Homo sapiens | hyaluronic acid oligomers | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.2.1.35 | 5 | - |
- |
Homo sapiens |
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