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Literature summary extracted from

  • Luan, L.; Sugiyama, T.; Takai, S; Usami, Y.; Adachi, T.; Katagiri, Y.; Hirano, K.
    Purification and characterization of pranlukast hydrolase from rat liver microsomes: the hydrolase is identical to carboxylesterase pI 6.2 (1997), Biol. Pharm. Bull., 20, 71-75.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.1 bis(4-nitrophenyl) phosphate
-
 Rattus norvegicus
3.1.1.1 EDTA no inhibition Rattus norvegicus
3.1.1.1 PMSF
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.1 0.0512
-
 pranlukast isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.061
-
 pranlukast isoenzyme pI 6.2 Rattus norvegicus
3.1.1.1 0.0688
-
 delapril isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.0689
-
 anisilic acid isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.0702
-
 anisamidobutyric acid isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.0804
-
 benazepril isoenzyme pI 6.2 Rattus norvegicus
3.1.1.1 0.0842
-
 diltiazem isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.1002
-
 benazepril isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.1177
-
 procaine isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.1202
-
 delapril isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.126
-
 anisamidobutyric acid isoenzyme pI 6.2 Rattus norvegicus
3.1.1.1 0.1336
-
 capsaicin isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.141
-
 camostat mesilate isoenzyme pI 6.2 Rattus norvegicus
3.1.1.1 0.15
-
 anisilic acid isoenzyme pI 6.2 Rattus norvegicus
3.1.1.1 0.229
-
 temocapril isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.2324
-
 camostat mesilate isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.3297
-
 imidapril isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.38
-
 diltiazem isoenzyme pI 6.2 Rattus norvegicus
3.1.1.1 0.4075
-
 imidapril isoenzyme pI 6.2 Rattus norvegicus
3.1.1.1 0.4678
-
 temocapril isoenzyme pI 6.2 Rattus norvegicus
3.1.1.1 0.4992
-
 trinotecan isoenzyme pI 6.2 Rattus norvegicus
3.1.1.1 0.715
-
 trinotecan isoenzyme pI 6.0 Rattus norvegicus
3.1.1.1 0.9284
-
 oxybutynin isoenzyme pI 6.0 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.1 microsome
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.1 58000
-
 3 * 58000, isoenzyme pI 6.0, SDS-PAGE Rattus norvegicus
3.1.1.1 60000
-
 isoenzyme pI 6.2, gel filtration Rattus norvegicus
3.1.1.1 174000
-
 isoenzyme pI 6.0, gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.1 two isoenzymes: pI 6.0 and pI 6.2 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 4-nitrophenyl acetate + H2O
-
 Rattus norvegicus 4-nitrophenol + acetate
-
 ?
3.1.1.1 anisamidobutyric acid + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.1 anisilic acid + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.1 benazepril + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.1 camostat mesilate + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.1 capsaicin + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.1 delapril + H2O
-
 Rattus norvegicus N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine + ethanol
-
 ?
3.1.1.1 diltiazem + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.1 imidapril + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.1 naphthyl acetate + H2O
-
 Rattus norvegicus naphthol + acetate
-
 ?
3.1.1.1 oxybutynin + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.1 pranlukast + H2O effectively hydrolyzed by carboxylesterase pI 6.2 but not by the pI 6.0 enzyme Rattus norvegicus ?
-
 ?
3.1.1.1 procaine + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.1 temocapril + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.1 trinotecan + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.1 monomer 1 * 60000, isoenzyme pI 6.2, SDS-PAGE Rattus norvegicus
3.1.1.1 trimer 3 * 58000, isoenzyme pI 6.0, SDS-PAGE Rattus norvegicus