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Literature summary extracted from

  • Palcic, M.M.; Scaman, C.H.; Otter, A.; Szpacenko, A.; Romaniouk, A.; Li, Y.X.; Vijay, I.K.
    Processing alpha-glucosidase I is an inverting glycosidase (1999), Glycoconj. J., 16, 351-355.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.106 pharmacology enzyme is an inhibitor target for antiviral agents that interfere with the formation of essential glycoproteins required in viral assembly, secretion and infectivity Saccharomyces cerevisiae
3.2.1.106 pharmacology enzyme is an inhibitor target for antiviral agents that interfere with the formation of essential glycoproteins required in viral assembly, secretion and infectivity Bos taurus
3.2.1.106 pharmacology glucosidase I may be a target for antiviral and antitumor drugs, glucosidase I inhibitors are potentially useful as antiviral, antitumor and antimetastatic agents Saccharomyces cerevisiae
3.2.1.106 pharmacology glucosidase I may be a target for antiviral and antitumor drugs, glucosidase I inhibitors are potentially useful as antiviral, antitumor and antimetastatic agents Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.106 microsome
-
 Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.106 Glc3Man9GlcNAc2 + H2O Saccharomyces cerevisiae hydrolyses specifically terminal alpha1,2-linked glucose residue ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Bos taurus hydrolyses specifically terminal alpha1,2-linked glucose residue ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Saccharomyces cerevisiae specific involvement in the N-linked oligosaccharide-processing pathway ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Bos taurus specific involvement in the N-linked oligosaccharide-processing pathway ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Saccharomyces cerevisiae involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Bos taurus involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Saccharomyces cerevisiae involved in processing of asparagine-linked oligosaccharides ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O Bos taurus involved in processing of asparagine-linked oligosaccharides ?
-
 ?
3.2.1.106 additional information Saccharomyces cerevisiae involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
3.2.1.106 additional information Bos taurus involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins ?
-
 ?
3.2.1.106 additional information Saccharomyces cerevisiae involved in processing of asparagine-linked oligosaccharides ?
-
 ?
3.2.1.106 additional information Bos taurus involved in processing of asparagine-linked oligosaccharides ?
-
 ?
3.2.1.106 additional information Saccharomyces cerevisiae significant role in protein folding by allowing the binding of glycoproteins to the endoplasmic reticulum chaperones calnexin and calreticulin ?
-
 ?
3.2.1.106 additional information Bos taurus significant role in protein folding by allowing the binding of glycoproteins to the endoplasmic reticulum chaperones calnexin and calreticulin ?
-
 ?
3.2.1.106 additional information Saccharomyces cerevisiae key enzyme in the biosynthesis of asparagines-linked oligosaccharides catalyzing the first processing event after the en bloc transfer of Glc3Man9GlcNAc2 to proteins ?
-
 ?
3.2.1.106 additional information Bos taurus key enzyme in the biosynthesis of asparagines-linked oligosaccharides catalyzing the first processing event after the en bloc transfer of Glc3Man9GlcNAc2 to proteins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.106 Bos taurus
-
-
-
3.2.1.106 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.106
-
 Saccharomyces cerevisiae
3.2.1.106 lactating mammary gland Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.2.1.106 Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose mechanism Saccharomyces cerevisiae
a
3.2.1.106 Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose mechanism Bos taurus
a
3.2.1.106 Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose stereochemistry, enzyme is an inverting glycosidase, operates with inversion of anomeric configuration Saccharomyces cerevisiae
a
3.2.1.106 Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose stereochemistry, enzyme is an inverting glycosidase, operates with inversion of anomeric configuration Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.106 mammary gland
-
 Bos taurus
-
3.2.1.106 mammary gland lactating mammary glands Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.1.106 additional information
-
-
 Saccharomyces cerevisiae
3.2.1.106 additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.106 alpha-D-Glc-(1-2)-alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 + H2O
-
 Saccharomyces cerevisiae beta-D-glucose + alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 formation of alpha-glucose is delayed with respect to beta-glucose: enzyme operates with inversion of anomeric configuration ?
3.2.1.106 alpha-D-Glc-(1-2)-alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 + H2O
-
 Bos taurus beta-D-glucose + alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 formation of alpha-glucose is delayed with respect to beta-glucose: enzyme operates with inversion of anomeric configuration ?
3.2.1.106 alpha-D-Glc-(1-2)-alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 + H2O synthetic substrate, formation of the product demonstrates that the enzyme operates with inversion of anomeric configuration Saccharomyces cerevisiae beta-D-glucose + alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3
-
 ?
3.2.1.106 alpha-D-Glc-(1-2)-alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 + H2O synthetic substrate, formation of the product demonstrates that the enzyme operates with inversion of anomeric configuration Bos taurus beta-D-glucose + alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O
-
 Saccharomyces cerevisiae D-glucose + Glc2Man9GlcNAc2
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O
-
 Bos taurus D-glucose + Glc2Man9GlcNAc2
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Saccharomyces cerevisiae D-glucose + Glc2Man9GlcNAc2
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Bos taurus D-glucose + Glc2Man9GlcNAc2
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Saccharomyces cerevisiae ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Bos taurus ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O specific involvement in the N-linked oligosaccharide-processing pathway Saccharomyces cerevisiae ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O specific involvement in the N-linked oligosaccharide-processing pathway Bos taurus ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Saccharomyces cerevisiae ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Bos taurus ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O involved in processing of asparagine-linked oligosaccharides Saccharomyces cerevisiae ?
-
 ?
3.2.1.106 Glc3Man9GlcNAc2 + H2O involved in processing of asparagine-linked oligosaccharides Bos taurus ?
-
 ?
3.2.1.106 additional information also acts, more slowly, on the corresponding glycolipids and glycopeptides Saccharomyces cerevisiae ?
-
 ?
3.2.1.106 additional information also acts, more slowly, on the corresponding glycolipids and glycopeptides Bos taurus ?
-
 ?
3.2.1.106 additional information p-nitrophenyl-glucosides: no substrates Saccharomyces cerevisiae ?
-
 ?
3.2.1.106 additional information p-nitrophenyl-glucosides: no substrates Bos taurus ?
-
 ?
3.2.1.106 additional information involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Saccharomyces cerevisiae ?
-
 ?
3.2.1.106 additional information involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins Bos taurus ?
-
 ?
3.2.1.106 additional information involved in processing of asparagine-linked oligosaccharides Saccharomyces cerevisiae ?
-
 ?
3.2.1.106 additional information involved in processing of asparagine-linked oligosaccharides Bos taurus ?
-
 ?
3.2.1.106 additional information significant role in protein folding by allowing the binding of glycoproteins to the endoplasmic reticulum chaperones calnexin and calreticulin Saccharomyces cerevisiae ?
-
 ?
3.2.1.106 additional information significant role in protein folding by allowing the binding of glycoproteins to the endoplasmic reticulum chaperones calnexin and calreticulin Bos taurus ?
-
 ?
3.2.1.106 additional information key enzyme in the biosynthesis of asparagines-linked oligosaccharides catalyzing the first processing event after the en bloc transfer of Glc3Man9GlcNAc2 to proteins Saccharomyces cerevisiae ?
-
 ?
3.2.1.106 additional information key enzyme in the biosynthesis of asparagines-linked oligosaccharides catalyzing the first processing event after the en bloc transfer of Glc3Man9GlcNAc2 to proteins Bos taurus ?
-
 ?