Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Adams, A.; Redden, C.; Menahem, S.
    Characterization of human fructose 1,6-bisphosphatase in control and deficient tissues (1990), J. Inherit. Metab. Dis., 13, 829-848.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.11 citrate activates Homo sapiens
3.1.3.11 EDTA activation Homo sapiens
3.1.3.11 His activation Homo sapiens
3.1.3.11 NH4+ 0.01-0.02 mM, slight activation of neutral and alkaline isoenzyme, progressive inhibition at increasing concentration Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.11 K+ at 5 mM Mg2+, increasing K+ up to 140 mM are progressively inhibitory for neutral and alkaline isoenzyme from liver, muscle neutral isoenzyme is activated, 10% at 5 mM Mg2+ but inhibited at 1 mM Mg2+ Homo sapiens
3.1.3.11 NH4+ 0.01-0.02 mM, slight activation of neutral and alkaline isoenzyme, progressive inhibition at increasing concentration Homo sapiens
3.1.3.11 Zn2+ 0.001-0.010 mM has no significant effect, with 0.002-0.0035 mM Zn2+, in absence of EDTA, 50% inhibition, 80% inhibition by 0.01 mM Zn2+ Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.11 0.002
-
 fructose 1,6-diphosphate alkaline isoenzyme Homo sapiens
3.1.3.11 0.0034
-
 fructose 1,6-diphosphate neutral isoenzyme Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.11 K+ at 5 mM Mg2+, increasing K+ up to 140 mM are progressively inhibitory for neutral and alkaline isoenzyme from liver, muscle neutral isoenzyme is activated, 10% at 5 mM Mg2+ but inhibited at 1 mM Mg2+ Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.11 D-fructose 1,6-diphosphate + H2O Homo sapiens the alkaline isoenzyme may have an important role in vivo in the regulation and control of glycolysis and glyconeogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.11 liver
-
 Homo sapiens
-
3.1.3.11 muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.11 D-fructose 1,6-diphosphate + H2O the alkaline isoenzyme may have an important role in vivo in the regulation and control of glycolysis and glyconeogenesis Homo sapiens ?
-
 ?
3.1.3.11 D-fructose 1,6-diphosphate + H2O
-
 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.3.11 70
-
 half-life of neutral isoenzyme: 710 s, half-life of alkaline isoenzyme: 764 s Homo sapiens