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Literature summary extracted from
- Replacing tryptophan-128 of T4 endonuclease V with a serine residue results in decreased enzymatic activity in vitro and in vivo (1995), Nucleic Acids Res., 23, 3764-3770.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.25.1 | DNA + H2O | Tequatrovirus T4 | - |
? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.25.1 | Tequatrovirus T4 | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.25.1 | WT-enzyme and W128S | Tequatrovirus T4 |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate | cleavage on the 5'-side of dimers | Tequatrovirus T4 | |
| 3.1.25.1 | endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate | 2-step mechanism, pyrimidine dimer-DNA glycosylase and an apurinic/apyrimidinic endonuclease | Tequatrovirus T4 |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.25.1 | infected cell | T4 infected | Tequatrovirus T4 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.25.1 | DNA + H2O | - |
Tequatrovirus T4 | ? | - |
? | |
| 3.1.25.1 | poly(dA)-poly(dT) + H2O | UV-irradiated | Tequatrovirus T4 | oligonucleotides | - |
? | |
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