EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
6.3.5.3 | 6-diazo-5-oxo-L-norleucine | competitive analogue of Gln binds irreversibly at the Gln active site | Gallus gallus | |
6.3.5.3 | albizziin | competitive analogue of Gln binds irreversibly at the Gln active site | Gallus gallus | |
6.3.5.3 | Cyanate | - |
Gallus gallus | |
6.3.5.3 | hydroxylamine | - |
Gallus gallus | |
6.3.5.3 | iodoacetamide | - |
Gallus gallus | |
6.3.5.3 | iodoacetate | - |
Gallus gallus | |
6.3.5.3 | O-diazoacetyl-L-Ser | i.e. L-azaserine, competitive analogue of Gln binds irreversibly at the Gln active site | Gallus gallus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.3.5.3 | 0.1 | - |
5'-phosphoribosylformylglycinamide | - |
Gallus gallus | |
6.3.5.3 | 0.2 | - |
Gln | - |
Gallus gallus | |
6.3.5.3 | 0.4 | - |
ATP | - |
Gallus gallus | |
6.3.5.3 | 80 | 100 | NH4+ | - |
Gallus gallus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
6.3.5.3 | Mg2+ | required | Gallus gallus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
6.3.5.3 | 133000 | 135000 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
6.3.5.3 | 133000 | 135000 | - |
Gallus gallus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.5.3 | Gallus gallus | - |
- |
- |
6.3.5.3 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
6.3.5.3 | - |
Gallus gallus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
6.3.5.3 | ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate | Gln adds first to the enzyme with ATP and 5'-phosphoribosylformylglycinamide adding randomly subsequently | Gallus gallus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
6.3.5.3 | liver | - |
Gallus gallus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
6.3.5.3 | additional information | - |
- |
Gallus gallus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.5.3 | ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu | - |
? | |
6.3.5.3 | ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O | - |
Gallus gallus | ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu | - |
? | |
6.3.5.3 | ATP + 5'-phosphoribosylformylglycinamide + NH4+ + H2O | - |
Gallus gallus | ADP + phosphate + 5'-phosphoribosylformylglycinamidine | - |
? | |
6.3.5.3 | ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O | ATP in form of MgATP2- | Gallus gallus | ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate | - |
? | |
6.3.5.3 | additional information | glutamyl derivatives, e.g. gamma-glutamylhydroxamate, gamma-glutamyl hydrazine, gamma-glutamyl esters, and gamma-glutamyl thioesters are hydrolyzed with strict dependence on Mg2+, ATP, and 5'-phosphoribosylformylglycinamide | Gallus gallus | ? | - |
? |