Literature summary extracted from

Elliott, W.L.; Weber, G.
Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (1984), Cancer Res., 44, 2430-2434.

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
6.3.5.3	0.03	-	L-Gln	liver and hepatoma 3924A	Rattus norvegicus
6.3.5.3	0.06	-	5'-phosphoribosylformylglycinamide	liver and hepatoma 3924A	Rattus norvegicus
6.3.5.3	1.5	-	ATP	liver and hepatoma 3924A	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.5.3	Homo sapiens	-	-	-
6.3.5.3	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
6.3.5.3	brain	-	Rattus norvegicus	-
6.3.5.3	colon	-	Rattus norvegicus	-
6.3.5.3	colonic carcinoma cell	-	Homo sapiens	-
6.3.5.3	heart	-	Rattus norvegicus	-
6.3.5.3	hepatoma cell	16, 20, 44, 7787, 7777, 3924A, 5123tc	Rattus norvegicus	-
6.3.5.3	liver	-	Rattus norvegicus	-
6.3.5.3	lung	-	Rattus norvegicus	-
6.3.5.3	additional information	increased activity in replicating cells and in tumors	Homo sapiens	-
6.3.5.3	additional information	increased activity in replicating cells and in tumors	Rattus norvegicus	-
6.3.5.3	renal cell carcinoma cell	-	Homo sapiens	-
6.3.5.3	renal cortex	-	Rattus norvegicus	-
6.3.5.3	skeletal muscle	-	Rattus norvegicus	-
6.3.5.3	small intestine	-	Rattus norvegicus	-
6.3.5.3	spleen	-	Rattus norvegicus	-
6.3.5.3	testis	-	Rattus norvegicus	-
6.3.5.3	thymus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.5.3	ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O	-	Homo sapiens	ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu	-	?
6.3.5.3	ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O	-	Rattus norvegicus	ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu	-	?

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.3.5.3	7.4	-	liver and hepatoma 3924A	Rattus norvegicus

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Release 2023.1 (January 2023)