Literature summary extracted from

Saheki, T.; Tsuda, M.; Takada, S.; Kusumi, K.; Katsunuma, T.
Role of argininosuccinate synthetase in the regulation of urea synthesis in the rat and argininosuccinate synthetase-associated metabolic disorder in man (1986), Adv. Enzyme Regul., 18, 221-238.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6.3.4.5	additional information	Homo sapiens	adult-type citrullinemia with neuro-psychiatric symptoms of late onset, 24-28 years old, caused by argininosuccinate synthetase abnormalities	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.4.5	Homo sapiens	-	adult-type citrullinemia with neuro-psychiatric symptoms of late onset, 24-28 years old, caused by ASS abnormalities	-
6.3.4.5	Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.4.5	ATP + L-citrulline + L-Asp	-	Homo sapiens	AMP + diphosphate + L-argininosuccinate	-	?
6.3.4.5	ATP + L-citrulline + L-Asp	-	Rattus norvegicus	AMP + diphosphate + L-argininosuccinate	-	?
6.3.4.5	additional information	adult-type citrullinemia with neuro-psychiatric symptoms of late onset, 24-28 years old, caused by argininosuccinate synthetase abnormalities	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)